Press release
MeiraGTx Announces Upcoming Presentations at the Association for Research in Vision and Ophthalmology (ARVO) 2023 Annual Meeting
LONDON and NEW YORK, April 21, 2023 (GLOBE NEWSWIRE) -- MeiraGTx Holdings plc (Nasdaq: MGTX), a vertically integrated, clinical stage gene therapy company,
About this update from Meiragtx Holdings Plc
[{"type":"text","content":"LONDON and NEW YORK, April 21, 2023 (GLOBE NEWSWIRE) -- MeiraGTx Holdings plc (Nasdaq: MGTX), a vertically integrated, clinical stage gene therapy company, today announced two abstract presentations at the Association for Research in Vision and Ophthalmology (ARVO) 2023 Annual Meeting. The first abstract will present humoral immune response data from the Company’s Phase 1/2 MGT009 trial for the investigational gene therapy botaretigene sparoparvovec (bota-vec, formerly AAV-RPGR) in patients with the inherited retinal disease (IRD) X-linked retinitis pigmentosa (XLRP) associated with the retinitis pigmentosa GTPase regulator (RPGR) gene which is being developed along with our partners Janssen Pharmaceuticals, Inc. (Janssen), one of the Janssen Pharmaceutical Companies of Johnson & Johnson. The second abstract will present data from MeiraGTx’s proprietary promoter platform involving the use of novel, AI-assisted engineered promoters to improve gene expression in rod photoreceptors. “We are pleased to present recent data from the Phase 1/2 clinical study of our investigational gene therapy bota-vec at this year’s ARVO meeting. An understanding of the immune response of bota-vec in XLRP patients is important as we move forward in the late stage development of this product with the aim of providing a safe and effective treatment for patients with this irreversible and devastating disease,” said Alexandria Forbes, Ph.D., president, and chief executive officer of MeiraGTx. “In addition, I am very excited to present some of the first data from our AI driven promoter discovery platform as exemplified by the rod-specific promoters we are presenting. Our AI driven promoter discovery platform provides us the ability to rapidly and accurately achieve cell specific as well as gene-appropriate expression levels in any cell type, accelerating the development of optimized potent and safe gene therapy vectors targeting different cell types and tissues, including different neuronal sub-types. The rod specific promoters presented are being applied to our optogenetic vectors targeting rods to allow these photoreceptors to respond more like cones, a potential treatment for central vision loss in diseases such as Dry AMD, as well as for rod or rod-cone disorders.” Presentation/poster #: 5446: Humoral immune response to AAV5-RPGR (botaretigene sparopar...