Press release
MeiraGTx Announces Oral Presentation at the 2024 American Academy of Oral Medicine (AAOM) Annual Conference
LONDON and NEW YORK, April 18, 2024 (GLOBE NEWSWIRE) -- MeiraGTx Holdings plc (Nasdaq: MGTX), a vertically integrated, clinical stage gene therapy company,
About this update from Meiragtx Holdings Plc
[{"type":"text","content":"LONDON and NEW YORK, April 18, 2024 (GLOBE NEWSWIRE) -- MeiraGTx Holdings plc (Nasdaq: MGTX), a vertically integrated, clinical stage gene therapy company, today announced the Company gave an oral presentation at the American Academy of Oral Medicine Annual Conference, being held from April 16-20, 2024, at the Hyatt Regency Grand Cypress in Orlando, FL. The details of the oral presentation are below: Session: Oral Abstract Session IPresentation ID #196Title: Results of a Phase 1, Open-label, Dose-escalation Study of Gene Therapy with AAV2-hAQP1 as Treatment for Grade 2 and 3 Radiation-induced Late Xerostomia and Parotid Gland Hypofunction – The AQUAx StudyPresenting Author: Dr. Michael BrennanTime: 4:20pm ET Abstract:Results of a Phase 1, Open-label, Dose-escalation Study of Gene Therapy with AAV2-hAQP1 as Treatment for Grade 2 and 3 Radiation-induced Late Xerostomia and Parotid Gland Hypofunction Michael Brennan5, Michael Passineau1, Deborah Saunders4, Herve Sroussi2, Dyani Gaudilliere3, Arthur Fernandez1, Jun Liu1, Nathalie Dubois1, Robert Zeldin11MeiraGTx, New York, NY; 2Brigham and Women's Hospital, Boston, MA; 3Stanford University, Palo Alto, CA; 4Health Sciences North, Sudbury, ON, Canada; 5Atrium Health, Charlotte, NC; ObjectivesGrade 2/3 late xerostomia is a chronic, debilitating complication of radiotherapy for head and neck cancers. We assessed the safety and efficacy of AAV2-hAQP1 gene therapy as a treatment for this condition. MethodsTwenty-four participants with Grade 2/3 xerostomia at least five years after completing radiotherapy (2 years if HPV+) were enrolled in this multi-center, open-label, dose-escalation study. AAV2-hAQP1 was delivered to the parotid gland(s) via cannulation of Stensen’s duct. Twelve participants received AAV2-hAQP1 in one gland and 12 in both glands. Participants were followed for 12 months post-treatment. Safety parameters included adverse events, physical examinations, laboratory tests, and electrocardiograms. Efficacy assessments included the Xerostomia-specific Questionnaire (XQ), MD Anderson Symptom Inventory-Head and Neck Module (MDASI-HN), Global Rate of Change Questionnaire (GRCQ), and measurement of unstimulated and stimulated whole saliva flow rates (UWSFR, SWSFR). ResultsNo treatment-related serious adverse events or dose-limiting toxicities were reported, and all participants co...