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MediWound Announces Positive Initial Data from its U.S. Phase I/II Study of MW005 for the Treatment of Basal Cell Carcinoma
MW005 Shown to Be Safe and Well-ToleratedTarget Lesions Clearance Data Provides Clinical Efficacy Proof-of-Concept YAVNE, Israel, July 11, 2022 (GLOBE
About this update from Mediwound Ltd.
[{"type":"text","content":"MW005 Shown to Be Safe and Well-ToleratedTarget Lesions Clearance Data Provides Clinical Efficacy Proof-of-Concept YAVNE, Israel, July 11, 2022 (GLOBE NEWSWIRE) -- MediWound Ltd. (Nasdaq: MDWD) (the “Company”), a fully-integrated biopharmaceutical company focused on next-generation biotherapeutic solutions for tissue repair and regeneration, today announced positive initial data from eleven patients in its ongoing open-label Phase I/II study of MW005 for the treatment of low-risk Basal Cell Carcinoma (BCC). The initial data shows MW005 to be safe and well-tolerated, with a majority of the patients who completed the study achieving complete histological clearance of their target lesions following treatment with MW005. The Company anticipates announcing the final data in the second half of 2022. In the first cohort, eleven patients with either superficial or nodular BCC were treated. Patients enrolled into the study received seven topical applications of MW005, once every other day. At the end of eight weeks post treatment period, all patients undergo complete excision, and the specimen is subject to an independent histological clearance examination. Based on the data generated to date, MW005 is safe, well-tolerated and an effective treatment for BCC with a majority of patients who completed the study demonstrating a complete histological clearance of target lesions. “Non-melanoma skin cancers are the most common of all types of cancer and represent a significant potential market opportunity for MediWound,” said Ofer Gonen, Chief Executive Officer of MediWound. “We recognize that there is a high unmet need for a non-surgical treatment that achieves high rates of clinical and histological clearance with a safe profile. The data continues to validate our technology, providing us with multiple strategic alternatives to advance the development of this asset.” Prof. Lior Rosenberg, Chief Medical Technology Officer at MediWound said, “These encouraging results from the Phase I/II clinical trial of MW005 suggest that we are on a path to potentially offer a topical treatment for patients with BCC that would be an alternative to surgical excision of these lesions. The data is in line with the previously published clinical experience we had and provides further clinical proof-of-concept.” BCC is a non-melanoma skin cancer that arises from t...