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MediciNova Announces Positive Findings on MN-001 (tipelukast) in Acute Liver Injury Model to be Presented at The Liver Meeting Digital Experience™ 2020
LA JOLLA, Calif., Oct. 13, 2020 (GLOBE NEWSWIRE) -- MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the
About this update from Medicinova, Inc.
[{"type":"text","content":"LA JOLLA, Calif., Oct. 13, 2020 (GLOBE NEWSWIRE) -- MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (Code Number: 4875), today announced positive findings from a study evaluating MN-001 (tipelukast) in an acute liver injury model will be presented at The Liver Meeting Digital Experience™ 2020 (TLMdX™), an event of the American Association for the Study of Liver Diseases (AASLD). The study is the results of a collaborative effort between MediciNova and Dr. Craig McClain and Dr. Leila Gobejishvili at the University of Lousiville School of Medicine.\n The poster presentation entitled \"MODULATION OF TGFβ1 SIGNALING BY INTERACTION OF cAMP EFFECTORS AND TGFβ1 TYPE I RECEPTOR IN HEPATIC STELLATE CELLS\" is authored by principal researcher, Dr. Leila Gobejishvili, Associate Professor, University of Louisville School of Medicine, Division of Gastroenterology, Hepatology and Nutrition. Due to the COVID-19 pandemic, TLMdX™ will be held November 13-16, 2020 in its digital format. The poster session will be open and available during the entirety of TLMdX™ 2020. Presentation details are as follows: Publication Number: 0317 Session Title: Basic Fibrosis Research and Stellate Cell Biology Presentation Type: Poster Presentation Dates: November 13-16, 2020 About MN-001 MN-001 (tipelukast) is a novel, orally bioavailable, small molecule compound thought to exert its effects through several mechanisms to produce its anti-inflammatory and anti-fibrotic activity in preclinical models, including leukotriene (LT) receptor antagonism, inhibition of phosphodiesterases (PDE) (mainly 3 and 4), and inhibition of 5-lipoxygenase (5-LO). The 5-LO/LT pathway has been postulated as a pathogenic factor in fibrosis development, and MN-001's inhibitory effect on 5-LO and the 5-LO/LT pathway is considered to be a novel approach to treat fibrosis. MN-001 has been shown to down-regulate expression of genes that promote fibrosis including LOXL2, Collagen Type 1 and TIMP-1. MN-001 has also been shown to down-regulate expression of genes that promote inflammation including CCR2 and MCP-1. In addition, histopathological data shows that MN-001 reduces fibrosis in multiple animal models. About MediciNova MediciNova, Inc. is a publicly traded biopharmaceutical company founded up...