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MediciNova Announces Completion of Enrollment in the Phase 2b Clinical Trial of MN 166 (ibudilast) in Alcohol Use Disorder
LA JOLLA, Calif., Jan. 30, 2023 (GLOBE NEWSWIRE) -- MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the
About this update from Medicinova, Inc.
[{"type":"text","content":"LA JOLLA, Calif., Jan. 30, 2023 (GLOBE NEWSWIRE) -- MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (Code Number: 4875), today announced that the Phase 2b clinical trial evaluating MN-166 (ibudilast) for the treatment of alcohol use disorder (AUD) has completed enrollment. This clinical trial was funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The NIAAA R01 research funding (R01AA026190) was awarded to Principal Investigator Dr. Lara Ray, PhD, ABPP, at the University of California, Los Angeles' (UCLA) Departments of Psychology, and Psychiatry and Biobehavioral Sciences Brain Research Institute. The clinical trial evaluated MN-166 (ibudilast) as a potential treatment to decrease alcohol consumption in treatment-seeking individuals diagnosed with AUD. MediciNova provided drug supply and regulatory support for the clinical trial. Lara Ray, PhD, Principal Investigator of the study, commented, “We have completed enrollment and are conducting follow-up on the last of the participants. Recent studies of MN-166 (ibudilast) have shown it to be a safe and promising compound for the treatment of AUD and we are eager to begin the analysis.” Kazuko Matsuda, MD, PhD, MPH, Chief Medical Officer of MediciNova, Inc., commented, “We appreciate the continued grant support for this program by the NIH, Dr. Ray’s team for their outstanding conduct of the trial, and all of the participants who contributed to the successful completion of enrollment. We are pleased that enrollment has completed and look forward to the reporting of topline results.” About the Clinical Trial This study is a randomized, double-blind, placebo-controlled, outpatient clinical trial which enrolled 102 treatment-seeking men and women with moderate or severe AUD. Participants took MN-166 (ibudilast) 50 mg or placebo twice a day for 12 weeks and completed the NIAAA-developed web-based program Take Control during the study. The primary endpoint of the trial is to test whether MN-166 (ibudilast) will decrease percent heavy drinking days (defined as ≥5 drinks for men and ≥4 drinks for women), as compared to placebo, over the course of the 12-week trial. The secondary endpoints are to test the efficacy of MN-166 (ibudilast) on 1) the number of drinks consumed per...