Business
Medicenna Presents Data on MDNA11, an IL-2 Superkine at ASCO 2020
Medicenna Presents Data on MDNA11, an IL-2 Superkine at ASCO 2020 Canada NewsWire ...
About this update from Medicenna Therapeutics Corp.
[{"type":"text","content":"\n\n\n\nMedicenna Presents Data on MDNA11, an IL-2 Superkine at ASCO 2020\n\n/* Style Definitions */\nspan.prnews_span\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\na.prnews_a\n{\ncolor:blue;\n}\nli.prnews_li\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\np.prnews_p\n{\nfont-size:0.62em;\nfont-family:\"Arial\";\ncolor:black;\nmargin:0in;\n}\n.prntac{\nTEXT-ALIGN: CENTER\n}\n\n\n\n\n\n\n\nCanada NewsWire\nTORONTO, May 29, 2020\n\n\n\n-MDNA11, a long acting IL-2 super-agonist shows potent and durable tumor control with strong memory response in tumor models--Up to 10-fold expansion of cancer-killing immune cells in non-human primates (NHP) without underlying safety issues or immunogenicity-\n TORONTO, May 29, 2020 /CNW/ - Medicenna Therapeutics Corp.  (\"Medicenna\" or \"the Company\") (TSX: MDNA, OTCQB: MDNAF), a clinical stage immuno-oncology company, today announced virtual presentation of data on MDNA11, one of its lead candidates from the IL-2 Superkine program, at the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting.\nThe poster presentation by Dr. Moutih Rafei, PhD, (Associate Professor of Pharmacology and Physiology at the University de Montreal) focuses on new data arising from MDNA11, Medicenna's novel long-acting interleukin-2 (IL-2) Superkine program. \n\"Recent transactions in the immuno-oncology and IL-2 space are evidence of the industry demand for drug candidates that can effectively boost the immune system of patients undergoing cancer treatment. The data we are sharing at ASCO show that MDNA11 has the potential to be a best-in-class IL-2 asset,\" says Dr. Fahar Merchant, Chief Executive Officer, Medicenna. \"We are impressed by MDNA11's preclinical profile, including its selectivity for immune effector cells, pharmacokinetics, safety and preclinical efficacy. We look forward to progressing MDNA11 towards the clinic in the next 12 months and to share these data with the ASCO community.\"\nThe poster presentation focuses on encouraging data in NHP for MDNA11, a long-acting IL-2 variant engineered to have enhanced affinity to CD122 without interacting with CD25. This allows MDNA11 to specifically expand cancer fighting naïve CD8 T cells as well as natural killer (NK) cells with minimal stimulation of T regulatory cells (Tregs) and eosinophils (associated with va...