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MDNA55 Shows Promising Results in Models of Ovarian Cancer
MDNA55 Shows Promising Results in Models of Ovarian Cancer Canada NewsWire TORON...
About this update from Medicenna Therapeutics Corp.
[{"type":"text","content":"\n\n\n\nMDNA55 Shows Promising Results in Models of Ovarian Cancer\n\n/* Style Definitions */\nspan.prnews_span\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\na.prnews_a\n{\ncolor:blue;\n}\nli.prnews_li\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\np.prnews_p\n{\nfont-size:0.62em;\nfont-family:\"Arial\";\ncolor:black;\nmargin:0in;\n}\n.prntac{\nTEXT-ALIGN: CENTER\n}\n\n\n\n\n\n\n\nCanada NewsWire\nTORONTO and HOUSTON, June 26, 2019\n\n\n\nScientists at the NIH and FDA Demonstrate Impressive Synergy of MDNA55 with Interferons  \n TORONTO and HOUSTON, June 26, 2019 /CNW/ - Medicenna Therapeutics Corp. (\"Medicenna\" or the \"Company\") (TSX: MDNA; OTCQB: MDNAF), a clinical stage immuno-oncology company, is pleased to announce new data on MDNA55 was published in the March 2019 issue of the journal Immunotherapy.  The authors of the publication entitled \"Combination immunotherapy with IL-4- Pseudomonas exotoxin and IFN-α and IFN-γ mediate synergistic antitumor effects in vitro and in a mouse model of human ovarian cancer\", are investigators in different branches of the National Institutes of Health (NIH) and FDA's Center for Biologics Evaluation & Research.  \nIn the published pre-clinical data, MDNA55 (IL-4 fused to Pseudomonas exotoxin) was shown to effectively target and kill ovarian cancer cells overexpressing the IL-4 receptor (IL4R), consistent with previous data showing the antitumor effect of MDNA55.  New results have now shown that MDNA55, when combined with approved drugs called interferons (IFN-α and IFN-γ), act in a highly synergistic fashion to kill tumor cells and increase survival in an aggressive mouse model of metastatic ovarian cancer without causing damage to vital organs.  These data suggest that this novel combination could provide a unique and effective approach to treating ovarian cancer. \nOvarian cancer is the seventh most common cancer in women worldwide with over 250,000 new cases diagnosed annually. Ovarian cancer is a difficult and trying disease where more than half of the patients treated with conventional therapy simply do not respond. Because it is most often diagnosed in its advanced stage, the prognosis for women with ovarian cancer has been very poor. Historical progression-free survival in ovari...