Press release
New Study Suggests That Masimo SedLine® Brain Function Monitoring May Aid Early Identification of Patients at Risk of Developing Postoperative Delirium
NEUCHATEL, Switzerland--(BUSINESS WIRE)-- Masimo (NASDAQ: MASI) today announced the findings of a prospective study published in Anesthesia & Analgesia in
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[{"type":"text","content":" NEUCHATEL, Switzerland--(BUSINESS WIRE)--\nMasimo (NASDAQ: MASI) today announced the findings of a prospective study published in Anesthesia & Analgesia in which Dr. Claudia Spies and colleagues investigated the relationship between parameters derived from electroencephalogram (EEG) spectra, measured using Masimo SedLine® Brain Function Monitoring, and postoperative delirium (POD) in older patients undergoing elective surgery. The researchers found that the incidence of POD correlated with several spectral dynamics, in particular spectral edge frequency (SEF), suggesting that such EEG-based markers may help in early identification of patients at risk of developing POD.1\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211212005095/en/Masimo Root® with SedLine® Brain Function Monitoring (Photo: Business Wire)\nPOD is a frequent complication in geriatric patients, often associated with worse short- and long-term outcomes and long-term cognitive dysfunction. Noting that the incidence of POD is associated with prolonged EEG burst suppression during general anesthesia, the researchers sought to investigate whether specific preoperative, preexisting EEG signatures might be related to a higher risk of developing POD.\n\nThe investigators enrolled 237 patients ≥ 65 years scheduled for elective surgery of at least 60 minutes at the Charité-Universitätsmedizin Berlin (Campus Virchow Klinikum and Campus Mitte) between November 2014 and December 2016. Using Masimo Root® with SedLine, frontal EEGs were recorded from before induction of anesthesia until return of consciousness. The researchers used the SedLine data to analyze a variety of EEG-derived parameters, including SEF (the frequency below which 95% of the power in the EEG is located), Patient State Index (a processed EEG parameter related to the effect of anesthetic agents), and duration of burst suppression, and also performed multitaper spectral analyses to calculate overall frontal power spectra across various frequency bands. Screening for POD was performed twice every day until the seventh day after surgery (or until hospital discharge) based on a variety of standard criteria, including the Nursing Delirium Screening Scale and Confusion Assessment Method. Patients with one or more positive screenings were classed as PO...