Press release
New Study Finds That Use of Masimo SedLine® PSi and DSA May Significantly Reduce Postoperative Delirium
NEUCHATEL, Switzerland--(BUSINESS WIRE)-- Masimo (NASDAQ: MASI) today announced the findings of a prospective study published in Frontiers in Neurology in
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[{"type":"text","content":" NEUCHATEL, Switzerland--(BUSINESS WIRE)--\nMasimo (NASDAQ: MASI) today announced the findings of a prospective study published in Frontiers in Neurology in which Dr. Na Xu and colleagues at Capital Medical University in Beijing investigated whether general anesthesia guided by Masimo SedLine® Brain Function Monitoring parameters on Root® could reduce the incidence of postoperative delirium (POD) in patients undergoing carotid endarterectomy (CEA). Using a combination of SedLine’s Patient State Index (PSi), an index based on processed electroencephalogram (EEG), and the Density Spectral Array (DSA), which represents the power of the EEG on both sides of the brain, to guide anesthesia during the procedure, the researchers found a significantly reduced risk of postoperative delirium, and concluded that patients “may benefit from the monitoring of multiple EEG parameters during surgery.”1\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211114005316/en/Masimo Root® with SedLine® Brain Function Monitoring (Photo: Business Wire)\nThe researchers noted that cerebral blood supply may be “severely disrupted” during CEA, the gold standard treatment for severe carotid stenosis, and that cerebral function is “highly vulnerable” to even brief changes in oxygen and blood supply, as well as to cerebral vascular diseases like carotid stenosis. POD is a “common yet serious” type of geriatric neurological dysfunction associated with worse short- and long-term prognosis and higher healthcare costs. Noting that the incidence of POD is associated with the duration of EEG suppression during surgery, they sought to investigate whether monitoring multiple processed EEG parameters simultaneously to guide anesthesia during a procedure like CEA could positively impact the incidence of POD, compared to use of a single parameter alone.\n\nThe authors enrolled 255 patients scheduled for CEA and divided them randomly into an intervention group (n=127, mean age 62) and a standard group (n=128, mean age 63). In the intervention group, general anesthesia was managed using a combination of Masimo SedLine PSi and DSA monitoring (designed to reduce the risk of intraoperative EEG burst suppression); in the standard group, PSi without DSA monitoring was used. In both groups, patients were also monitored wi...