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Marizyme Inc. Announces Results of GOAL Study Presented at 7th Annual International Coronary Congress
Marizyme Inc. Announces Results of GOAL Study Presented at 7th Annual International Coronary Congress.
About this update from Marizyme, Inc.
[{"type":"text","content":"\n JUPITER, FL, Dec. 03, 2021 (GLOBE NEWSWIRE) -- via NewMediaWire – Marizyme Inc. (MRZM), a biotechnology company engaged in the development and commercialization of products to prevent, treat and diagnose diseases of unmet clinical need announced today that results of the GOAL Study (Vienna Heart Center Floridsdorf/PI Dr. Winkler Bernhard) were presented by Dr. Maximillian Y.  Emmert  (German Heart Center and Charite Universitatsmedizin, Berlin Germany) Friday, December 3 at the 7th  Annual International Coronary Congress in New York City. The GOAL Study is an independent investigator observational clinical study to assess the role of vascular graft /storage solutions on myocardial protection during coronary artery bypass grafting (CABG) surgeries. The study was conducted at the Vienna Heart Center Floridsdorf and the Karl Landsteiner Institute for Cardio-Vascular Research, Vienna, Austria under the direction of principal investigator, Dr. Bernhard Winkler. The study was comprised of two cohorts, each cohort consisting of 83 propensity-matched patients undergoing “on-pump” CABG surgery. Patients in the first cohort received DuraGraft® Vascular Conduit Solution (Somahlution LLC, Jupiter, FL) both for storage of venous and arterial free conduits prior to surgical anastomosis and as a flushing solution down the grafts to check the integrity of the distal anastomosis. Patients in the second cohort received Standard of Care, 0.9% Saline/Biseko (Biotest Pharma GmbH, Dreiech, Germany). In this study, the use of DuraGraft Solution was found to be associated with statistically significant reductions in perioperative high-sensitivity Troponin-I levels beginning at day 1 and persisting through day 6 post-CABG surgery. Peak levels of hs troponin-I were also substantially reduced in patients receiving DuraGraft, with the greatest difference noted at 12-24 hours post CABG surgery. Troponin-I is a marker of ischemic myocardial damage and significantly lower troponin levels suggest that perfusion of the distal vascular beds and downstream myocardium following flushing with DuraGraft confers enhanced myocardial protection compared to standard of care. Repeated flushing of the graft preservation solution down the vascular conduits to test the distal anastomosis was demonstrated to be safe. Clinical data has...