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TriLink BioTechnologies, Part of Maravai LifeSciences, Expands its mRNA Raw Material Offering with the First GMP-grade Modified Nucleoside-Triphosphate Product
TriLink now offers GMP-grade N1-Methyl-Pseudouridine-5’-Triphosphate, a critical raw material for mRNA manufacturing, allowing researchers to accelerate their
About this update from Maravai Lifesciences Holdings, Inc.
[{"type":"text","content":"TriLink now offers GMP-grade N1-Methyl-Pseudouridine-5’-Triphosphate, a critical raw material for mRNA manufacturing, allowing researchers to accelerate their drug discovery and development timelines and US-source their supply chain\nSAN DIEGO, Sept. 13, 2022 (GLOBE NEWSWIRE) -- TriLink BioTechnologies (TriLink), a Maravai LifeSciences company (Maravai) (NASDAQ: MRVI) and global provider of life science reagents and services, has expanded its GMP-grade product offering to include N1-Methyl-Pseudouridine-5’-Triphosphate (N1meΨTP), a modified nucleoside-triphosphate (NTP) essential for mRNA manufacturing. This new product extension leverages TriLink’s quality systems and GMP capabilities, including cleanroom manufacturing, expanded analytical testing, and process verification. The demand for N1-Methyl-pseudouridine modified mRNA has risen significantly in the past several years due to its incorporation in both FDA-approved mRNA vaccines against COVID-19. “A key aspect of the COVID-19 mRNA vaccines is the use of a modified base, N1-methyl-pseudouridine, instead of the standard uridine base,” said Kate Broderick, Ph.D., Senior Vice President of R&D, TriLink BioTechnologies. “This modification is essential for the mRNA vaccine to work because otherwise, the delicate mRNA is quickly degraded by the immune system.” TriLink was an early pioneer in this space as one of the first manufacturers of N1meΨTP. “Our team has been manufacturing N1-Methyl-Pseudouridine-5’-Triphosphate for over ten years now, gaining significant expertise,” said Jeremy Horton, Senior Vice President of Manufacturing Operations, TriLink BioTechnologies. “Our analytical capabilities for mRNA raw materials are unmatched, so it made strategic sense to apply that same level of process control to other products in our catalog.” Together with its revolutionary CleanCap® co-transcriptional mRNA capping reagent, already in billions of mRNA vaccine doses worldwide, offering GMP-grade N1-methyl-pseudouridine at GMP grade strengthens TriLink’s commitment to enabling the industry to bring breakthrough mRNA-based therapies to the clinic. “N1-Methyl-Pseudouridine is a key raw material for the majority of mRNA therapeutics we see in development today. Our GMP-grade N1-Methyl-Pseudouridine-5’-Triphosphate allows us to address our customer’s needs to domestically source materials,” ...