Business
MannKind to Present Two Posters at 22nd Annual Diabetes Technology Meeting
Technosphere® Insulin (TI) peaked 30 minutes faster and significantly reduced postprandial glucose excursions (PPGE) at 60 minutes compared to subcutaneous
About this update from Mannkind Corporation
[{"type":"text","content":"Technosphere® Insulin (TI) peaked 30 minutes faster and significantly reduced postprandial glucose excursions (PPGE) at 60 minutes compared to subcutaneous insulinsThe Afrezza with Basal Combination (ABC) Study demonstrated similar glucose control between the three treatment groups; data to be presented and published in 2023 WESTLAKE VILLAGE, Calif., Nov. 10, 2022 (GLOBE NEWSWIRE) -- MannKind Corporation (Nasdaq: MNKD), a company focused on the development and commercialization of inhaled therapeutic products and devices for patients with endocrine and orphan lung diseases, announced today that it will present data from two posters on November 10 during the 22nd Annual Diabetes Technology Meeting’s virtual poster session. “We are excited to present initial findings from the Afrezza with Basal Combination (ABC) proof-of-concept study, which demonstrated significantly improved postprandial glucose excursions with TI compared to subcutaneous insulin during an in-office meal challenge,” said Dr. Kevin Kaiserman, Vice President of Medical Affairs and Safety for MannKind’s Endocrine Business Unit. Dr. Kaiserman will present poster# DESB2134D, which showed that: TI peaked 30 minutes faster and significantly reduced glucose at 60 minutes compared to subcutaneous insulins – including recently approved versions. The mean PPGE at 60 minutes for TI measured 57.9 mg/dL compared to 101.4 mg/dL for subcutaneous insulins – a reduction of 43.5 mg/dL. No severe hypoglycemia was observed in the TI groups using the higher dose conversion method described below. “Providing inhaled insulin as a potential pump-sparing option is an intriguing finding from this pilot study,” said Michael Castagna, PharmD, Chief Executive Officer for MannKind Corporation. “MannKind remains committed to improving options for mealtime control for patients living with diabetes.” The ABC study took patients currently using their Automated Insulin Delivery (AID) device and randomized them into three groups – a control group that continued to use their system with current subcutaneous insulin, a second group that added TI for mealtime insulin in combination with the AID system, and a third group that used long-acting insulin degludec once a day with TI for all meals and corrections (instead of the AID system). Twenty-one adult randomized participants (≥ 18 years) with T1D and ...