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Longeveron Receives Intent to Grant Notice from the European Patent Office for Methods to Monitor Efficacy of Lomecel-B™ Cell Therapy Through Levels of Vascular Biomarker
Issued claims will protect use of a biomarker to assess response to Lomecel-B™ in patients with blood vessel dysfunction MIAMI, Aug. 25, 2022 (GLOBE NEWSWIRE)
About this update from Longeveron Inc.
[{"type":"text","content":"Issued claims will protect use of a biomarker to assess response to Lomecel-B™ in patients with blood vessel dysfunction\nMIAMI, Aug. 25, 2022 (GLOBE NEWSWIRE) -- Longeveron Inc. (NASDAQ: LGVN), a clinical stage biotechnology company developing cellular therapies for chronic, aging-related and life-threatening conditions, today announced that the European Patent Office (EPO) has issued a notice of its intent to grant the Company a patent (EP Application No. 15861319.0) related to methods to treat endothelial dysfunction and monitor the efficacy of allogeneic mesenchymal cell therapies, also known as medicinal signaling cells (MSCs). The cells are administered to patients with cardiovascular disease through the monitoring of a protein, Vascular Endothelial Growth Factor (VEGF), which is a signal protein produced by many cells that stimulates the formation of blood vessels. “We are extremely pleased to receive this notice from the European patent office,” said Chris Min, M.D., Ph.D., Interim Chief Executive Officer and Chief Medical Officer at Longeveron. “This patent will bolster our robust intellectual property portfolio and support our goal of delivering effective cell therapies for a range of aging-related and life-threatening conditions.” The patent is titled “Methods for Monitoring Efficacy of Allogeneic Mesenchymal Stem Cell Therapy in a Subject.” Longeveron’s lead investigational product is Lomecel-B™, a cell therapy product derived from MSCs. Many of Longeveron’s clinical studies point to Lomecel-B™ exerting effects through pro-vascular functions and/or reducing endothelial dysfunction, a condition where the lining of blood vessels is abnormal leading to diminished health of blood vessels and blood flow regulation. The Company is evaluating the use of MSCs to treat several indications, including Hypoplastic Left Heart Syndrome (HLHS), a rare and life-threatening congenital heart defect that affects approximately 1,000 babies per year. Longeveron received both a Rare Pediatric Disease Designation and Orphan Drug Designation from the United States Food and Drug Administration in 2021 for Lomecel-B™ for the treatment of infants with HLHS. Longeveron is currently evaluating Lomecel-B™ for HLHS in a Phase 2a trial. Longeveron is also conducting a trial of Lomecel-B™ in patients with Alzheimer’s Disease in the US and for aging ...