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Lantheus Highlights Preliminary Study Results Demonstrating Potential of NM-01, a Novel Technetium-99m SPECT/CT Imaging Agent, to Assess PD-L1 Expression for Immunotherapy in Cancer
Study Results Presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting NORTH BILLERICA, Mass., June 13, 2022 (GLOBE NEWSWIRE)
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[{"type":"text","content":"Study Results Presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting\nNORTH BILLERICA, Mass., June 13, 2022 (GLOBE NEWSWIRE) -- Lantheus Holdings, Inc. (“the Company”) (NASDAQ: LNTH) is committed to improving patient outcomes through diagnostics, radiotherapeutics and artificial intelligence solutions that enable clinicians to Find, Fight and Follow disease. Lantheus presented preliminary results of the PD-L1 Expression in Cancer (PECan) study at the Society of Nuclear Medicine and Molecular Imaging Annual Meeting. The results suggest that NM-01, a proprietary technetium 99m SPECT/CT imaging agent currently under development to assess PD-L1 expression in cancer cells, has the potential to identify patients who will respond to checkpoint inhibitor therapies and monitor early response in non-small cell lung cancer (NSCLC) pending further and ongoing investigation. In the preliminary analysis, investigators were able to evidence intertumoral heterogeneity of PD-L1 expression between primary tumors and metastases. Further, baseline NM-01 SPECT/CT imaging was able to predict early metabolic 18F-FDG PET/CT response to anti-PD-L1 therapy in primary and metastatic tumors. Following therapy, PD-L1 expression measured by NM-01 SPECT/CT imaging demonstrated stability or a reduction in the majority of responding lesions. “Immune checkpoint inhibition with PD-1 or PD-L1 alone or in combination with chemotherapy is a standard of care in the management of NSCLC. However, the methods currently used to measure PD-L1 expression, based on immunohistochemistry (IHC) assessment of biopsied tissue samples, are often suboptimal, making it difficult to select which patients will respond to therapy. The PECan study sets out to assess the relationship between PD-L1 expression as measured by NM-01 and metabolic response to anti-PD-L1 therapy in NSCLC,” said Gary Cook, MD, King’s College London, and principal investigator of the study. “Based on these initial findings, we are encouraged that NM-01 may play a role in identifying positive patient response to immune checkpoint inhibitor therapy.” The PECan study (NCT04436406) is planned to enroll 15 advanced NSCLC and 15 melanoma patients. The presentation reported the results of the first 10 NSCLC patients (median age: 64; 6 male, 4 female). Thoracic NM-01 SPECT/CT imaging ...