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Lantheus Announces Collaboration to Support Prostate Cancer Clinical Development
Novartis will include PYLARIFY® (piflufolastat F18) in their clinical trials for Pluvicto™ (lutetium Lu 177 vipivotide tetraxetan) for the selection of
About this update from Lantheus Holdings, Inc.
[{"type":"text","content":"Novartis will include PYLARIFY® (piflufolastat F18) in their clinical trials for Pluvicto™ (lutetium Lu 177 vipivotide tetraxetan) for the selection of patients with prostate cancer\nNORTH BILLERICA, Mass., March 29, 2022 (GLOBE NEWSWIRE) -- Lantheus Holdings, Inc. (“the Company”) (NASDAQ: LNTH), an established leader and fully integrated provider committed to innovative imaging diagnostics, targeted therapeutics and artificial intelligence solutions to Find, Fight and Follow serious medical conditions, today announced a strategic collaboration with Novartis to include PYLARIFY® (piflufolastat F18) in prostate cancer clinical trials with Pluvicto™ (lutetium Lu 177 vipivotide tetraxetan). “The FDA-approval of Novartis’ Pluvicto brings hope to patients and is an exciting advancement in the field of radiopharmaceutical oncology,” said Mary Anne Heino, President and CEO of Lantheus. “We look forward to collaborating to further explore how PSMA PET imaging agents, like PYLARIFY, may aid in increasing accessibility to PSMA-targeted therapeutics. As always, our goal is to Find, Fight and Follow serious medical conditions and improve patient outcomes.” PYLARIFY, approved by the FDA in May 2021, is the first commercially and widely available prostate-specific membrane antigen (PSMA) PET imaging agent. The collaboration with Novartis directly aligns with Lantheus’ strategy to advance cancer precision medicine by enabling partners to use PYLARIFY in prostate cancer therapeutic trials. As part of the agreement with Novartis, Lantheus will provide PYLARIFY for the selection of patients with prostate cancer and Novartis will provide all PYLARIFY related clinical imaging data to Lantheus. The Company believes the approval of a PSMA-targeted therapeutic for the treatment of adult patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who have already been treated with other anticancer treatments (androgen receptor pathway inhibition and taxane-based chemotherapy) creates a new addressable market for the use of PSMA PET imaging in patient selection for PSMA-targeted therapy. As a result, the Company estimates the U.S. Total Addressable Market (TAM) for all PSMA PET imaging increases by approximately 30,000 de novo scans per year for this mCRPC patient population. The Company now estimates the TAM to be 250,000 scans,...