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Kymera Therapeutics Presents Positive Preclinical Data on Selective STAT3 Degraders for Hematological and Solid Tumor Malignancies at 63rd American Society of Hematology (ASH) Annual Meeting
Two presentations demonstrated Kymera’s STAT3 degraders can reduce STAT3 expression, modify STAT3-dependent signaling, and suppress the growth of tumors in
About this update from Kymera Therapeutics, Inc.
[{"type":"text","content":"Two presentations demonstrated Kymera’s STAT3 degraders can reduce STAT3 expression, modify STAT3-dependent signaling, and suppress the growth of tumors in multiple preclinical models of lymphoma and solid tumors WATERTOWN, Mass., Dec. 13, 2021 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a biopharmaceutical company advancing targeted protein degradation to deliver novel, small molecule protein degrader therapeutics, today announced the company presented new preclinical data for its STAT3 degraders, including its first-in-class KT-333 STAT3 degrader, at the virtual 63rd American Society of Hematology (ASH) Annual Meeting taking place from December 11 – 14, 2021 in Atlanta, GA and virtually. Kymera’s first presentation, “A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers” showcased how its clinical compound KT-333 induced growth arrest and cell death in multiple models of anaplastic large cell lymphoma (ALCL). This resulted in eradication of ALK+ ALCL tumor xenografts with weekly or every other week dosing associated with >90% STAT3 knockdown in tumors and modulation of STAT3-dependent signaling. In addition, KT-333 reduced mediators of immune suppression in an ex vivo, co-culture model of the tumor microenvironment in non-small cell lung cancer and led to tumor regressions in the mouse CT-26 colorectal cancer syngeneic tumor model when coupled with an anti-PD1 antibody, demonstrating the potential for this combination immunodulatory approach in solid tumors. “KT-333 is a potent and selective STAT3 degrader targeting a high priority, previously undruggable transcription factor that has the potential to address a range of hematologic and solid cancers based on a growing body of preclinical studies described to date,” said Nello Mainolfi, PhD, Co-Founder, President and CEO, Kymera Therapeutics. “We are excited about the development opportunities as a monotherapy in STAT3-dependent T and NK cell hematologic malignancies and in combination with immune checkpoint inhibitors in solid tumors as we are about to initiate our Phase 1 trial in liquid and solid tumors.” The second presentation, “Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens” highlights results from a research collaboration with Georgio Inghirami, MD, Weil...