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Kymera Therapeutics Announces Positive First-in-Human Results from Phase 1 Healthy Volunteer Clinical Trial of KT-621, a First-in-Class, Oral STAT6 Degrader
Phase 1 healthy volunteer data of KT-621, a once-a-day STAT6 degrader, surpass Kymera’s target product profile, significantly derisking program and further
About this update from Kymera Therapeutics, Inc.
[{"type":"text","content":"Phase 1 healthy volunteer data of KT-621, a once-a-day STAT6 degrader, surpass Kymera’s target product profile, significantly derisking program and further validating its oral, biologics-like profile >90% mean STAT6 degradation in blood achieved at all doses above 1.5 mg Complete STAT6 degradation achieved in both blood and skin at all MAD doses ≥50 mg KT-621 impact on Th2 biomarkers in line or superior to dupilumab with median TARC reduction up to 37% and median Eotaxin-3 reduction up to 63% KT-621 was well-tolerated with a safety profile undifferentiated from placebo, with no serious adverse events, no severe adverse events, no treatment related adverse events in more than one subject, and no clinically relevant changes in vital signs, lab tests or ECGs KT-621 BroADen Phase 1b trial in moderate to severe atopic dermatitis (AD) actively recruiting, with data expected in 4Q25 Two parallel Phase 2b trials in AD and asthma planned to start in 4Q25 and 1Q26, respectively Company to hold video conference call and webcast today at 8:00 a.m. ET WATERTOWN, Mass., June 02, 2025 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing a new class of oral small molecule degrader medicines for immunological diseases, today announced positive clinical results from the Phase 1 healthy volunteer study of KT-621, its first-in-class, oral STAT6 degrader medicine. “Our primary objective was to demonstrate that KT-621 could achieve robust STAT6 degradation in blood and skin that was well tolerated, and these results go well beyond our expectations. Building from the compelling preclinical data demonstrating a dupilumab-like profile, this impressive dataset, the first reported clinical data for a STAT6-targeted medicine, is a powerful demonstration of what we believe is an impeccable translation into humans. KT-621’s degradation potency, tolerability and initial Th2 biomarker profile in healthy volunteers demonstrates its potential for the treatment of IL-4/IL-13-driven allergic diseases, and of Kymera’s strategy and ability to develop revolutionary oral small molecules with the activity and safety of injectable biologics,” said Nello Mainolfi, PhD, Founder, President and CEO, Kymera Therapeutics. Dr. Mainolfi continued, “Across every measure, the KT-621 Phase 1 results were exceptional. We...