Business
Krystal Biotech Announces Third Quarter 2025 Financial and Operating Results
$97.8 million in 3Q VYJUVEK revenue and $623.2 million since U.S. launch VYJUVEK launched in Germany in 3Q; launched in France and Japan in 4Q Updated U.S.
About this update from Krystal Biotech, Inc.
[{"type":"text","content":"$97.8 million in 3Q VYJUVEK revenue and $623.2 million since U.S. launch VYJUVEK launched in Germany in 3Q; launched in France and Japan in 4Q Updated U.S. VYJUVEK label expands eligible patient population and provides greater patient flexibility FDA grants platform technology designation CF interim results expected in 4Q Strong balance sheet, ending the quarter with $864.2 million in cash and investments PITTSBURGH, Nov. 03, 2025 (GLOBE NEWSWIRE) -- Krystal Biotech, Inc. (the “Company”) (NASDAQ: KRYS) today reported financial results for the third quarter ending September 30, 2025 and provided a business update. “It is immensely gratifying to see a growing number of DEB patients worldwide benefit from access to VYJUVEK, and we look forward to rapidly and sustainably expanding that number in the months ahead,” said Krish S. Krishnan, Chairman and CEO of Krystal Biotech. “With multiple near-term readouts, starting with cystic fibrosis in Q4, and a strong balance sheet, Krystal is well positioned to advance our pipeline and deliver transformative therapies to patients with serious and rare diseases.” VYJUVEK® (beremagene geperpavec-svdt, or B-VEC)for the Treatment of Dystrophic Epidermolysis Bullosa (DEB) The Company recorded $97.8 million in VYJUVEK net product revenue for the third quarter of 2025. Gross margin for the quarter was 96%.The Company has secured over 615 reimbursement approvals for VYJUVEK in the United States and continues to maintain strong access nationwide.In September, the United States Food and Drug Administration (FDA) approved a label update which expanded the VYJUVEK eligible patient population to include DEB patients from birth and provided patients greater flexibility with respect to VYJUVEK application, including the option for patients or their caregivers to apply VYJUVEK at home on their own.In late August, the Company launched VYJUVEK in Germany, its first commercial launch of VYJUVEK outside of the United States. The Company estimates that approximately 20 patients have been prescribed VYJUVEK therapy across Germany, with over 10 German centers prescribing VYJUVEK to date. The Company has started discussions with payers in Germany and expects pricing negotiations to continue until at least 2H 2026.In September, the Haute Autorité de Santé (HAS) in France approved early reimbursed access to VYJUVEK un...