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Kodiak Sciences Data at ARVO 2024 Highlight Depth of Early and Late-Phase Retina Pipeline including Advancements with High Drug-Antibody-Ratio Therapeutics Built on Kodiak's Antibody Biopolymer Conjugate (ABC) Platform
Tarcocimab clinical and non-clinical data highlight strong 6-month efficacy profile in diabetic retinopathy patients and continued favorable safety
About this update from Kodiak Sciences Inc
[{"type":"text","content":"Tarcocimab clinical and non-clinical data highlight strong 6-month efficacy profile in diabetic retinopathy patients and continued favorable safety profile.KSI-501 clinical and non-clinical data highlight multiple ascending dose safety, bioactivity and durability in treatment-naïve and treatment-experienced patients and next steps of Phase 3 development for KSI-501 and Phase 1b development for KSI-101.Novel small molecules and protein therapeutics highlight potential for targeted, high drug-antibody-ratio (DAR) conjugates built on Kodiak's ABC Platform.PALO ALTO, Calif., May 2, 2024 /PRNewswire/ -- Kodiak Sciences Inc. (Nasdaq: KOD), a biopharmaceutical company committed to researching, developing and commercializing transformative therapeutics to treat high prevalence retinal diseases, announced today that nine scientific presentations on its clinical and research pipeline programs will be made at the Association for Research in Vision and Ophthalmology (ARVO) 2024 Annual Meeting, being held from May 5 – 9 in Seattle, Washington.\n\n\"We present clinical and non-clinical data on our ABC Platform medicines tarcocimab and KSI-501. We also begin to disclose the progress and potential for our duet and triplet drug platform. Conjugates of different active pharmaceutical intermediates (API) such as proteins, peptides, macrocycles, oligonucleotides, and small molecules, all with high drug antibody ratio (DAR) and tailored release, can be designed and manufactured. We wrap these within the 15 years of science and development experience with our ABC Platform and its thousands of patient years of clinical safety data and our commercial scale manufacturing facility Ursus,\" said Dr. Victor Perlroth, Chief Executive Officer of Kodiak Sciences. \"With many companies focused on engineering a better biologic or a better small molecule, we are instead extending our ABC Platform to make copolymer conjugates that power a next generation of targeted, high-DAR, multi-specific and multi-modality therapeutic candidates with relevance for retinal and systemic diseases.\"\nPresentations on tarcocimab tedromer (KSI-301): \nTitle: Tarcocimab tedromer (KSI-301) 5mg: outcomes of the Phase 3 GLOW1 Study in patients with non-proliferative diabetic retinopathy.Session Title: Diabetic retinopathy ISession Date and Time: May 6, 2024; 8:30 – 10:15 AM PTPresenta...