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Kiora Pharmaceuticals Completes Last Patient, Last Visit in Phase 1B Trial of KIO-301 in Patients with Retinitis Pigmentosa
Encinitas, California--(Newsfile Corp. - September 18, 2023) - Kiora Pharmaceuticals (NASDAQ: KPRX) today announced the completion of the final patient's last
About this update from Kiora Pharmaceuticals, Inc.
[{"type":"text","content":"Encinitas, California--(Newsfile Corp. - September 18, 2023) - Kiora Pharmaceuticals (NASDAQ: KPRX) today announced the completion of the final patient's last endpoint evaluation from the ABACUS study of KIO-301. KIO-301 is A molecular photoswitch being evaluated in a Phase 1B clinical trial for vision restoration in late-stage Retinitis Pigmentosa (RP). Topline study results will be reported November 4 at the upcoming American Academy of Ophthalmology annual meeting.\nABACUS enrolled six patients and evaluated 12 eyes at three doses. The study is designed to assess several outcomes, including safety and tolerability, light perception, functional visual improvement, visual cortex activity via functional MRI, and patient-reported outcomes across varying levels of late-stage disease. Kiora recently reported promising preliminary results from ABACUS at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting in April 2023. Data showed consistent functional, imaging and patient-reported outcomes supportive of biological proof-of-concept.\n\"We remain fully committed to making a meaningful difference in the lives of those affected by inherited retinal diseases including Retinitis Pigmentosa,\" said Eric Daniels, M.D., Chief Development Officer at Kiora. \"The completion of last patient, last visit for ABACUS, the first-in-human study of KIO-301, is an important milestone in our ongoing effort to develop the first vision-restoring therapeutic for RP.\"\nIn addition to RP, KIO-301 is being considered for other rare inherited retinal diseases, including Choroideremia. The aim is to bring innovative small molecule photoswitches to a wide range of patients afflicted with blinding diseases.\nAbout Kiora Pharmaceuticals\nKiora Pharmaceuticals is a clinical-stage biotechnology company developing and commercializing products for the treatment of orphan retinal diseases. KIO-301 is being developed for the treatment of Retinitis Pigmentosa, and Kiora also plans to develop KIO-301 for Choroideremia and Stargardt's Disease. It is a molecular photoswitch that has the potential to restore vision in patients with inherited and/or age-related retinal degeneration. Kiora plans to develop KIO-104 for the treatment of posterior non-infectious uveitis. It is a next-generation, non-steroidal, immuno-modulatory and small molecule inhi...