Kiniksa Reports Data for Mavrilimumab in COVID-19 Pneumonia and Hyperinflammation and for Vixarelimab in Diseases Characterized by Chronic Pruritus

About this update from Kiniksa Pharmaceuticals International, Plc

[{"type":"text","content":"– Mavrilimumab treatment protocol in patients with severe COVID-19 pneumonia and hyperinflammation showed improved clinical outcomes compared to matched contemporaneous controls, including earlier weaning from supplemental oxygen, shorter hospitalizations, and no deaths –\n – Vixarelimab exploratory Phase 2 trial in diseases characterized by chronic pruritus showed encouraging efficacy results in 4 out of 5 cohorts; plaque psoriasis cohort achieved statistically significant reduction in weekly-average Worst-Itch Numeric Rating Scale (WI-NRS) at Week 8 – HAMILTON, Bermuda, May 11, 2020 (GLOBE NEWSWIRE) -- Kiniksa Pharmaceuticals, Ltd. (Nasdaq: KNSA) (“Kiniksa”), a biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutic medicines for patients with significant unmet medical need, today provided additional data from the open-label treatment protocol with mavrilimumab, an investigational fully-human monoclonal antibody that targets granulocyte macrophage colony stimulating factor receptor alpha (GM-CSFRα), in patients with severe coronavirus 2019 (COVID-19) pneumonia and hyperinflammation. The company also provided data from the exploratory Phase 2 trial for vixarelimab, an investigational fully-human monoclonal antibody that targets oncostatin M receptor beta (OSMRβ), in diseases characterized by chronic pruritus. “These data are consistent with the encouraging results we have seen across our pipeline to date,” said Sanj K. Patel, Chief Executive Officer and Chairman of the Board of Kiniksa. “We are seeing the potential broad utility of mavrilimumab as demonstrated by the treatment protocol in COVID-19 pneumonia and hyperinflammation as well as our clinical collaboration with Kite Gilead in CAR T cytokine storm and our Phase 2 development program in giant cell arteritis. Additionally, vixarelimab has a first-in-class mechanism of action with the potential to positively impact the lives of patients with chronic pruritic diseases. We are executing on our clinical timelines and continue to expect data from rilonacept, mavrilimumab and KPL-404 in the second half of the year.” Mavrilimumab Treatment Protocol in COVID-19 Pneumonia and Hyperinflammation The mavrilimumab open-label treatment protocol was a prospective, interventional, single-active-arm, single-center pilot experience in Italy1...

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