Kiniksa Highlights Phase 2 Study Data Showing the Corticosteroid-Sparing Effect of Rilonacept in Patients with Recurrent Pericarditis at the American College of Cardiology's 69th Annual Scientific Session

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[{"type":"text","content":"- Phase 2 study data show the potential for rilonacept treatment to eliminate or reduce the risk of corticosteroid-associated morbidity in recurrent pericarditis - - Enrollment complete for the pivotal Phase 3 trial of rilonacept in recurrent pericarditis (RHAPSODY); data expected in 2H 2020 -\n HAMILTON, Bermuda, March 30, 2020 (GLOBE NEWSWIRE) -- Kiniksa Pharmaceuticals, Ltd. (Nasdaq: KNSA) (“Kiniksa”), a biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutic medicines for patients with significant unmet medical need, recently highlighted a supplemental analysis from its Phase 2 clinical trial of rilonacept, an IL-1α and IL-1β cytokine trap, in a range of recurrent pericarditis populations. The analysis, which showed the corticosteroid-sparing effect of rilonacept treatment in the Phase 2 trial, was included in a virtual poster at the American College of Cardiology’s (ACC) 69th Annual Scientific Session. “Novel therapies which could eliminate or reduce the risk of significant corticosteroid-associated morbidity in recurrent pericarditis are needed,” said John F. Paolini, MD, PhD, FACC, Chief Medical Officer of Kiniksa. “The supplemental analysis presented virtually at ACC highlights the corticosteroid-sparing effect of rilonacept treatment in the study by enabling a reduction in corticosteroid dose or by obviating the need for corticosteroid use while on treatment.” Dr. Allan Klein, MD, of Cleveland Clinic and co-principal investigator for the trial, is the lead author of the virtual poster Corticosteroid Tapering and Discontinuation in a Phase 2 Study of Rilonacept in Recurrent Pericarditis. The materials are available through the Science section of Kiniksa’s website (www.kiniksa.com). Final data from the Phase 2 trial were presented at the American Heart Association (AHA) Scientific Sessions in November 2019. The data showed that rilonacept treatment in the study improved clinically meaningful outcomes associated with the unmet medical need in recurrent pericarditis, including resolution of pericarditis episodes, tapering and discontinuation of corticosteroids without pericarditis recurrence, reduction in recurrences of pericarditis episodes while on treatment and improved quality of life scores. In the supplemental analysis highlighted at ACC, patients from the Phase 2 clinic...

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