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Kezar Life Sciences Presents Positive Complete Results from the MISSION Phase 2 Trial Evaluating Zetomipzomib in Lupus Nephritis at the American College of Rheumatology Convergence 2022
Overall renal responses (ORR), measured as 50% or greater reduction in proteinuria from baseline, increased from 11 of 17 patients (64.7%) at end of
About this update from Kezar Life Sciences, Inc.
[{"type":"text","content":"\n\nOverall renal responses (ORR), measured as 50% or greater reduction in proteinuria from baseline, increased from 11 of 17 patients (64.7%) at end of treatment (Week 25) to 15 of 17 patients (88.2%) at end of study (Week 37). The median UPCR at end of study was 0.32.\n\n\nReduction in proteinuria was highly correlated with reduction in uCD163, a marker of renal inflammation. The anti-inflammatory activity was maintained up to 12 weeks following discontinuation of zetomipzomib as evidenced by additional reduction in proteinuria and slow recrudescence of SLE disease activity.\n\n\nSystemic lupus erythematosus disease activity scores including SLEDAI-2K and CLASI were reduced.\n\n\nZetomipzomib once-weekly continues to demonstrate a favorable safety and tolerability profile, with no evidence of immunosuppression, and no new safety signals during the follow-up period.\n\n\n SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--\nKezar Life Sciences, Inc. (Nasdaq: KZR), a clinical-stage biotechnology company discovering and developing breakthrough treatments for immune-mediated and oncologic disorders, today announced that it presented the complete data set from the MISSION Phase 2 clinical trial evaluating zetomipzomib in active lupus nephritis (LN) at the American College of Rheumatology (ACR) Convergence 2022 in Philadelphia, PA.\n\n“The MISSION Phase 2 results demonstrate the potential of zetomipzomib, a first-in-class, selective inhibitor of the immunoproteasome, to meaningfully reduce proteinuria, as well as reduce extra-renal manifestations of systemic lupus in patients with LN. By the end of study, the median UPCR was less than 0.5, a clinically important treatment goal. Additionally, the data showed improvements in the skin manifestations of lupus and patient reported outcomes of disease. Importantly, these benefits were accompanied by an overall reduction in the use of corticosteroids,” said Noreen R. Henig, M.D., Kezar’s Chief Medical Officer. “With a well-tolerated safety profile, anti-inflammatory activity, and without indications of suppressing the immune system, zetomipzomib is positioned to be a potentially important therapy for patients with LN and SLE, as well as other autoimmune diseases such as autoimmune hepatitis.” \n\nThe MISSION Phase 2 clinical trial was an open-label study designed to demonstrate the responder ra...