Health
The Phase III Study Data of Stapokibart for Seasonal Allergic Rhinitis Published in Nature Medicine
Keymed Biosciences Inc. (HKEX: 02162) ("Keymed" or the "Company") today announced that the prestigious medical journal Nature Medicine has published the results from the Phase III trial of its independently developed IL-4Rα antibody stapokibart, for the treatment of moderate-to-severe seasonal allergic rhinitis (SAR). The study, led by Professor Luo Zhang of Beijing Tongren Hospital, Capital Medical University, represents the world's first clinical report on an IL-4Rα-targeted biologic for SAR,
About this update from Keymed Biosciences, Inc.
[{"type":"text","content":"CHENGDU, China, April 5, 2025 /PRNewswire/ -- Keymed Biosciences Inc. (HKEX: 02162) ("Keymed" or the "Company") today announced that the prestigious medical journal Nature Medicine has published the results from the Phase III trial of its independently developed IL-4Rα antibody stapokibart, for the treatment of moderate-to-severe seasonal allergic rhinitis (SAR). The study, led by Professor Luo Zhang of Beijing Tongren Hospital, Capital Medical University, represents the world's first clinical report on an IL-4Rα-targeted biologic for SAR, underscoring Chinese scientists' pioneering role in allergic rhinitis innovation.","length":665,"tagName":"p"},{"type":"text","content":"The study demonstrated that stapokibart significantly alleviates clinical symptoms and improves quality of life in patients with moderate-to-severe SAR who remained inadequately controlled despite standard therapies. This breakthrough offers a transformative solution to a global health challenge, ushering in a new era of biologic treatments for allergic rhinitis and providing hope to hundreds of millions of patients worldwide.","length":430,"tagName":"p"},{"type":"text","content":"Innovative Mechanism Addresses Urgent Clinical Needs","length":52,"tagName":"p"},{"type":"text","content":"Allergic rhinitis (AR), a chronic inflammatory disease of the nasal mucosa, is triggered by environmental allergens in sensitized individuals. In recent years, its global prevalence has risen significantly. Despite standard therapies, over 50% of patients continue to experience inadequately controlled symptoms, a substantial unmet need that severely impacts quality of life and imposes a heavy socioeconomic burden, positioning AR as a critical public health challenge.","length":471,"tagName":"p"},{"type":"text","content":"The persistence and exacerbation of AR symptoms are primarily driven by amplified type 2 inflammatory cascades. Stapokibart, targeting the IL-4 receptor alpha subunit (IL-4Rα), dual-blocks both IL-4 and IL-13 signaling pathways. Through a multi-pronged approach—inhibiting T-cell activation and proliferation, suppressing B-cell activation and IgE synthesis, and reducing inflammatory cell infiltration—Stapokibart comprehensively attenuates allergic reactions, providing a novel therapeutic strategy for seasonal allergic rhinit...