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Wellbeing Subsidiary KGK Science Announces Publication of Safety Studies on Paraxanthine and Comparison to Caffeine Toxicity.
Wellbeing Subsidiary KGK Science Announces Publication of Safety Studies on Paraxanthine and Comparison to Caffeine Toxicity..
About this update from Wellbeing Digital Sciences Inc.
[{"type":"text","content":"\nWellbeing Digital Sciences Inc. (“Wellbeing” or the “Company”) (NEO: MEDI) (OTC: KONEF) (FRA: SQ2), an evidence-based mental healthcare company focused on the development and implementation of innovative clinical solutions, including psychedelic medicine and digital therapeutics as supported by clinical research, announced today that its wholly owned subsidiary KGK Science Inc. (“KGK”), completed preclinical safety studies for Rarebird Coffee (“Rarebird”), a manufacturer and own label distributor of coffee crafted with paraxanthine (Px), a caffeine replacement.\n\nKGK has authored a manuscript entitled “Paraxanthine safety and comparison to caffeine,” which was published in the journal “Frontiers in Toxicology on February 2, 2023. Paraxanthine, the predominant metabolite of caffeine, is found in small amounts in coffee and other plants. Our bodies routinely convert caffeine into Px, but the pharmacological effects resulting from this metabolism, have not been well characterized. Preclinical studies of safety, using Rarebird Coffee’s Px ingredients, were conducted as a first step prior to market entry. Px has been proposed as a safer alternative to caffeine for use in foods and beverages, and the comparison study to caffeine lends support this premise.\n\nThe extensive battery of safety tests suggested a lack of genetic toxicity and mutagenicity. Repeat-dose safety studies indicated a larger No-Observed-Adverse-Effect-Level (NOAEL) for Px in comparison to caffeine, suggesting an improved safety profile for Px. These findings further the scientific understanding of the safety profile for Px, a subject that has largely been ignored despite the prevalence of caffeine-containing food products in the marketplace.\n\n“This study represents an important first step to both further our understanding of caffeine safety and highlight the use of Px as a potential caffeine replacement” says Najla Guthrie, CEO of Wellbeing Digital and KGK.\n\n“The safety profile of Px, in comparison to caffeine, is apparent in this study. It is imperative that consumers understand how caffeine is metabolized and to know whether those metabolites are more or less safe than caffeine. The head-to-head comparison in this study suggests paraxanthine Px has an improved safety...