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Karyopharm Announces XPOVIO® (Selinexor) Clinical Data to be Presented at the American Society of Hematology 2019 Annual Meeting
-- Updated Results from the Pomalyst® and Kyprolis® Arms of the Phase 1b/2 STOMP Study Evaluating Selinexor in Combination with Other Approved Myeloma
About this update from Karyopharm Therapeutics Inc.
[{"type":"text","content":"-- Updated Results from the Pomalyst® and Kyprolis® Arms of the Phase 1b/2 STOMP Study Evaluating Selinexor in Combination with Other Approved Myeloma Therapies in Relapsed or Refractory Multiple Myeloma to be Highlighted --\n -- Other Key Presentations Include New Data from the STOMP Revlimid® Arm Evaluating Selinexor in Patients with Newly Diagnosed Multiple Myeloma, Along with New Data Investigating Selinexor in Patients whose Myeloma has Progressed Following Experimental CAR-T Therapy -- NEWTON, Mass., Nov. 06, 2019 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), an oncology-focused pharmaceutical company, today announced that thirteen abstracts have been selected for presentation, including one oral presentation, at the upcoming American Society of Hematology (ASH) 2019 Annual Meeting taking place December 7-10, 2019 in Orlando. Four key abstracts to be presented at the meeting will feature clinical data for XPOVIO® (selinexor), the Company’s first in class, oral SINE compound, including: updated data from the Pomalyst® (pomalidomide) and Kyprolis® (carfilzomib) arms of the Phase 1b/2 STOMP study evaluating selinexor in combination with backbone therapies in patients with relapsed or refractory multiple myeloma; new data from the Revlimid® (lenalidomide) plus selinexor arm of the Phase 1b/2 STOMP study evaluating this combination in patients with newly diagnosed multiple myeloma; and new data reporting on the use of selinexor in multiple myeloma patients whose disease has progressed following chimeric antigen receptor T-cell (CAR-T) therapy. “We are expecting another strong presence at ASH this year with thirteen selected abstracts, including one oral presentation,” said Sharon Shacham, PhD, MBA, Founder, President and Chief Scientific Officer of Karyopharm. “Of key interest will be updated data from two arms of the STOMP study; the arm investigating the all-oral regimen of selinexor and Pomalyst, and the arm investigating selinexor and Kyprolis. In both arms the response rates and safety profile remain highly encouraging. In addition, we look forward to a presentation describing new data from patients treated with selinexor-based regimens after their myeloma had progressed following experimental CAR-T therapy. Although based on a small sample size, all patients had a confirmed response when treated with sel...