Press release
KalVista Announces Publication of Additional KVD900 Data in Clinical & Experimental Allergy
CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)-- KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on
About this update from Kalvista Pharmaceuticals, Inc.
[{"type":"text","content":" CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)--\nKalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors, today announced the publication of new data in Clinical & Experimental Allergy characterizing KVD900, a novel, potent and selective oral inhibitor of plasma kallikrein, a critical mediator of attacks in patients with hereditary angioedema (HAE). In this new publication, orally administered KVD900 was shown to be quickly absorbed and provided rapid and near-complete inhibition of plasma kallikrein and strong suppression of kallikrein-kinin system activation in patients with HAE.\n\n“Based on these results, on-demand administration of KVD900 is further demonstrated to block the generation of plasma kallikrein and bradykinin in HAE patient plasma and thereby may provide an opportunity to halt and reverse HAE attacks,” said Andrew Crockett, Chief Executive Officer of KalVista. “These data provide the underlying basis for the clinical results we reported for our phase 2 trial of KVD900 in on-demand treatment of HAE attacks, and further support our ongoing phase 3 KONFIDENT trial for KVD900 in the same indication.”\n\nAdditional details can be found in the manuscript, which is available at: http://doi.org/10.1111/cea.14122. Clinical & Experimental Allergy is the official journal of the British Society for Allergy & Clinical Immunology.\n\nAbout KalVista Pharmaceuticals, Inc.\nKalVista Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors for diseases with significant unmet need. KalVista has developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME). KalVista is developing KVD900 as an oral on-demand therapy for acute HAE attacks and has initiated the Phase 3 KONFIDENT clinical trial. KVD824 is in development for prophylactic treatment of HAE, with the Phase 2 KOMPLETE clinical trial underway. In addition, KalVista’s oral Factor XIIa inhibitor program represents a new generation of therapies that may further improve the treatment of HAE for patients. In DME, an intravitreally admi...