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Jasper Therapeutics Announces Research Collaboration with AVROBIO to Evaluate JSP191 as Conditioning Agent in Clinical Studies of Ex Vivo Lentiviral Gene Therapy
REDWOOD CITY, Calif. and CAMBRIDGE, Mass. , Nov. 09, 2021 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (Nasdaq: JSPR), a biotechnology company focused on
About this update from Jasper Therapeutics, Inc.
[{"type":"text","content":"REDWOOD CITY, Calif. and CAMBRIDGE, Mass. , Nov. 09, 2021 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (Nasdaq: JSPR), a biotechnology company focused on hematopoietic stem cell therapeutics, today announced that it has entered into a non-exclusive research collaboration with AVROBIO, Inc. to evaluate the use of JSP191, Jasper's anti-CD117 monoclonal antibody, as a targeted conditioning agent option for patients with Fabry disease and/or Gaucher disease type 1 who are being treated with one of AVROBIO’s investigational ex vivo lentiviral gene therapies. “This collaboration with AVROBIO further expands the potential of JSP191 for use with lentiviral gene therapies,” said Bill Lis, executive chairman and chief executive officer of Jasper Therapeutics. “We believe the use of JSP191 in AVROBIO’s Fabry disease and/or Gaucher disease type 1 investigational gene therapy programs offers patients and doctors a compelling new option when it comes to matching a patient’s disease with a conditioning agent meeting their therapeutic goals and requirements.” “Jasper is focused on building a leading hematopoietic stem cell therapeutics company with the potential to bring one-time treatments to patients with blood cancers, rare monogenic diseases and autoimmune diseases. Our broad pipeline is led by JSP191, a clinical stage antibody for pre-transplant conditioning, and our engineered hematopoietic stem cells (eHSC), both of which have the potential to be transformative platforms,” added Mr. Lis. Each company will retain commercial rights to their respective technologies. About JSP191JSP191 is a humanized monoclonal antibody in clinical development as a conditioning agent that blocks stem cell factor receptor signaling leading to clearance of hematopoietic stem cells from bone marrow, creating an empty space for donor or genetically modified transplanted stem cells to engraft. To date, JSP191 has been evaluated in more than 90 healthy volunteers and patients. Two clinical trials for myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML) and severe combined immunodeficiency (SCID) are currently enrolling. Enrollment in five additional studies are planned in patients with severe autoimmune disease, Fanconi anemia, sickle cell disease, chronic granulomatous disease and GATA2 MDS who are undergoing hematopoietic cell transplantation.About Jasp...