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Jasper Therapeutics Announces JSP191 Phase 1b MDS/AML Late Breaking Data Presentation at the 2022 Transplantation & Cellular Therapy Tandem Meetings of ASTCT and CIBMTR
JSP191 is well tolerated with no treatment-related severe adverse events in 17 subjects with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in
About this update from Jasper Therapeutics, Inc.
[{"type":"text","content":"JSP191 is well tolerated with no treatment-related severe adverse events in 17 subjects with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in Ph1b dose expansion study17 of 17 subjects achieved successful engraftment with neutrophil recovery12 of 15 subjects with measurable residual disease (MRD) at screening achieved clearance of MRD REDWOOD CITY, Calif., Feb. 24, 2022 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ: JSPR), a biotechnology company focused on hematopoietic stem cell therapies, today announced that the preliminary data from a Phase 1b study of the Company’s JSP191 first-in-class anti-CD117 monoclonal antibody will be presented as a late breaking abstract at the 2022 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR Tandem Meetings (TCT), to be held in Salt Lake City, UT, from April 23-26, 2022. The data from 17 patients over the age of 60 with MDS or AML show JSP191, in combination with low dose radiation and fludarabine conditioning, to be well tolerated in an older population with no infusion toxicities observed and no JSP191-related serious adverse events. Furthermore, this regimen achieved engraftment with neutrophil recovery in all 17 of 17 subjects and clearance of MRD in 12 of 15 subjects positive for MRD at screening. “We are pleased that JSP191 efficacy and safety results continue to demonstrate the potential to expand stem cell therapy cures to a far greater number of patients than is possible today,” said William Lis, executive chairman and CEO, Jasper Therapeutics. “Hematopoietic stem cell transplant is considered curative in these patients, yet its use is limited by current, standard-of-care alkylating conditioning agents that are either ineffective or are associated with high treatment-related mortality. As the first MDS/AML transplant study for an antibody-based conditioning regimen, we believe that these preliminary results show that JSP191 can be developed as an important option for patients and are looking forward to discussions with the FDA on the potential for a pivotal study.” Abstract Details: Title - Preliminary Data from a Phase 1 Study of JSP191, an Anti-CD117 Monoclonal Antibody, in Combination with Low Dose Irradiation and Fludarabine Conditioning Is Well-Tolerated, Facilitates Chimerism and Clearance of Minimal Residual Disease in Older Adults with ...