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Jaguar Health's Study Shows Mytesi (Crofelemer) May Support Treatment of Diarrhea in Cancer Patients Receiving Targeted Therapy While Also Enabling Maintenance and Tolerability of a Higher Dose of the Selected TKI
SAN FRANCISCO, CA / ACCESSWIRE / October 22, 2019 / Jaguar Health, Inc. (NASDAQ:JAGX) ("Jaguar" or the "Company") announced additional findings today from the
About this update from Jaguar Health, Inc.
[{"type":"text","content":"SAN FRANCISCO, CA / ACCESSWIRE / October 22, 2019 / Jaguar Health, Inc. (NASDAQ:JAGX) (\"Jaguar\" or the \"Company\") announced additional findings today from the recently completed preclinical study evaluating the effects of Mytesi® (crofelemer) on diarrhea induced by a specific tyrosine kinase inhibitor (TKI). The study in healthy dogs was designed to reinforce a scientific rationale for the use of crofelemer when human patients undergo treatment with targeted cancer therapies including, but not limited to, TKIs with or without cycle chemotherapy.Specifically, the preclinical study showed that crofelemer treatment resulted in lesser incidence and severity of diarrhea with the maintenance and tolerability of a higher dose of the selected TKI. Funded by a third-party manufacturer of an FDA-approved TKI for human use, the study points to potential benefits that the Company hopes to see in future human studies of crofelemer's ability to provide symptomatic relief of noninfectious diarrhea in patients receiving a targeted cancer therapy in an adjuvant or metastatic setting.The results showed that the animals in the crofelemer groups received approximately 20% higher doses of the TKI than the animals in the placebo group through the four weeks of the treatment period. The TKI dose reductions over the four-week period were statistically higher for the control group compared to the crofelemer QID group and trending toward statistical significance in the BID group. In general, the treatment effect of crofelemer was 1.5 to 2.5 times better than placebo for multiple endpoints in this study.\"Crofelemer is in development for the possible indication of symptomatic relief of cancer therapy-related diarrhea (CTD). We are very excited about these preclinical results and are planning a pivotal trial in CTD patients to evaluate the effects of crofelemer in prevention and/or relief of CTD. Many patients on TKIs require drug holidays or dose reductions in their therapy due to diarrhea. Reduced frequency and severity of diarrhea will allow better maintenance to the therapeutic dose and dosing of any targeted therapies, potentially leading to better clinical outcomes,\" Lisa Conte, Jaguar's president and CEO, stated. \"As we've learned from recent business development discussions with cancer agent manufacturers, adoption and continued use of TKIs a...