Holding in Company

Phytopharm PLC 6 December 2001 Phytopharm PLC ( the 'Company') Notification of Major Interests in Shares The Company received a notification yesterday from M&G Investment Management Limited, informing them that as at the close of business on 4th December 2001, Prudential plc, and certain of its subsidiary companies have a notifiable interest of 1,901,189 ordinary shares, representing 4.978% of the issued ordinary share capital of the Company. 6th December, 2001 WestLB Panmure Limited