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Iovance Biotherapeutics Reports Second Quarter 2020 Financial Results and Provides a Corporate Update
Enrollment Completed in Pivotal Cohort 1 of C-145-04 Cervical Cancer Study SAN CARLOS, Calif., Aug. 06, 2020 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc.
About this update from Iovance Biotherapeutics, Inc.
[{"type":"text","content":"Enrollment Completed in Pivotal Cohort 1 of C-145-04 Cervical Cancer Study\nSAN CARLOS, Calif., Aug. 06, 2020 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a late-stage biotechnology company developing novel T cell-based cancer immunotherapies (tumor-infiltrating lymphocyte, TIL and peripheral-blood lymphocyte, PBL), today reported second quarter 2020 financial results and provided a corporate update.\n “During a strong first half of 2020 we completed dosing and reported early data for our pivotal melanoma program for lifileucel, announced data at AACR for our collaborator Moffitt’s TIL in non-small cell lung cancer, presented updated Cohort 2 data for lifileucel at ASCO, and successfully completed a public financing,” said Maria Fardis, Ph.D., MBA, Iovance President and Chief Executive Officer. “Iovance is now in an excellent position to execute our planned commercial launch while broadening our pipeline programs. The cumulative set of positive clinical data for lifileucel continue to support our planned BLA submission for this one-time treatment for metastatic melanoma. We are also pleased to report that our cervical cancer pivotal program has recently completed enrollment in Cohort 1, and we look forward to dosing the last few patients in the coming weeks. With the first potential cell therapy in solid tumors and a broadening TIL platform, we believe Iovance is the leader in development, manufacturing, and commercialization of TIL cell therapy for cancer.” Second Quarter 2020 Updates Clinical: TIL therapy, lifileucel, in Melanoma: updated data from the C-144-01 trial continue to support the potential for lifileucel as a one-time treatment for advanced melanoma.- Updated Cohort 2 data presented at ASCO 2020 showed an ORR of 36.4% with median duration of response not reached at 18.7 months of median study follow up (n=66).- Early Cohort 4 data showed 32.4% ORR at 5.3 months of median study follow up (n=68).TIL therapy, lifileucel, in Cervical cancer: enrollment in the pivotal Cohort 1 is complete in the C-145-04 study of lifileucel, previously known as LN-145, for advanced cervical cancer.TIL therapy in non-small cell lung cancer (NSCLC): active planning is underway for a registration-directed study, IOV-LUN-202, for LN-145 in NSCLC patients with defined unmet medical need.T-cell based therapies in additiona...