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Iovance Biotherapeutics Announces Clinical Data Updates for Lifileucel in Advanced Melanoma
Median Duration of Response Not Reached at 17.0 Months of Median Study Follow Up in C-144-01 Study Oral Presentation to Include Additional Cohort 2 Data from
About this update from Iovance Biotherapeutics, Inc.
[{"type":"text","content":"Median Duration of Response Not Reached at 17.0 Months of Median Study Follow Up in C-144-01 Study\n Oral Presentation to Include Additional Cohort 2 Data from C-144-01 Clinical Study at ASCO 2020 Virtual Scientific Program SAN CARLOS, Calif., May 13, 2020 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a late-stage biotechnology company developing novel T cell-based cancer immunotherapies, today announced new interim data from Cohort 2 in the C-144-01 study of lifileucel in advanced melanoma. These data will be part of an oral presentation at the American Society of Clinical Oncology’s (ASCO) upcoming ASCO20 Virtual Scientific Program, to be held May 29-31, 2020. “We are very excited to share our latest melanoma data at the upcoming ASCO oral presentation,” said Maria Fardis, Ph.D., president and chief executive officer of Iovance Biotherapeutics. “The interim data as reported in the abstract continue to support the durability of Iovance’s lifileucel TIL therapy, administered as a one-time treatment for patients with advanced melanoma. As of February 2020, the median duration of response had not been reached at 17 months of median study follow up. We look forward to providing additional updates during the oral presentation at the ASCO20 Virtual Scientific Program.” Updated interim results from Cohort 2 are available in the abstract titled, “Long-term follow up of lifileucel (LN-144) cryopreserved autologous tumor infiltrating lymphocyte therapy in patients with advanced melanoma progressed on multiple prior therapies.” As of the February 2, 2020 data cut off used for the abstract submitted to ASCO20, lifileucel shows a 36.4% overall response rate (n=66) and median duration of response (DOR) was not reached at 17.0 months of median study follow up. The patients had heavily pretreated metastatic melanoma with high baseline disease burden. They have progressed on multiple prior therapies (3.3 mean prior therapies), including anti-PD1 and BRAF/MEK inhibitors. The adverse event profile was consistent with the underlying advanced disease, lymphodepletion and IL-2 regimens. The abstract is available in the ASCO Meeting Library at https://meetinglibrary.asco.org. Further updates will be available during the oral presentation at the ASC20 Virtual Scientific Program. Details of the presentation are as follows: Title: Lo...