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Invivyd Announces Continued Neutralizing Activity of PEMGARDA™ (pemivibart) Against Dominant SARS-CoV-2 Variants KP.3.1.1 and LB.1, and Other Variants of Interest
New pseudovirus in vitro neutralization data show continued neutralizing activity of PEMGARDA™ (pemivibart) against KP.3.1.1, LB.1, and other SARS-CoV-2
About this update from Invivyd, Inc.
[{"type":"text","content":"New pseudovirus in vitro neutralization data show continued neutralizing activity of PEMGARDA™ (pemivibart) against KP.3.1.1, LB.1, and other SARS-CoV-2 variants testedCenter for Disease Control reports KP.3.1.1 is the only major variant increasing in proportionality nationallyVariants confirmed as susceptible to pemivibart in independent analyses contain key Q493E, s31del, and other mutations that are prominent in circulating SARS-CoV-2 variants Data submitted to FDA for anticipated timely updates to PEMGARDA™ Fact SheetPipeline candidate VYD2311 shows attractive neutralization potency against the same contemporary viruses WALTHAM, Mass., Sept. 03, 2024 (GLOBE NEWSWIRE) -- Invivyd, Inc. (Nasdaq: IVVD), a biopharmaceutical company devoted to delivering protection from serious viral infectious diseases, today announced that new pseudovirus in vitro neutralization data show continued neutralizing activity of PEMGARDATM (pemivibart) and pipeline candidate VYD2311 against dominant SARS-CoV-2 variants KP.3.1.1 and LB.1, and others tested. The Center for Disease Control (CDC) estimates that KP.3.1.1 accounted for 42.2% of circulating variants of SARS-CoV-2 for the last two weeks of August and is the only major variant increasing in proportionality nationally. Invivyd generated these new data as part of its ongoing industrial virology effort, which leverages a consistent, high-quality, independent, third-party pseudoviral system that routinely tests authentic Invivyd-produced pemivibart and is supported by extensive structure-based analytics. KP.3.1.1, LB.1, and other viruses now assessed and confirmed as susceptible to pemivibart contain key mutations prominent in circulating SARS-CoV-2 variants such as Q493E and the S31 deletion (del) that, while outside of the pemivibart binding site, can influence viral antibody evasion. As of September 2024, the primary structure of the pemivibart epitope has remained intact across 99.59% of viral sequences deposited in Global Initiative on Sharing All Influenza Data (GISAID) since the original Omicron BA.1 variant. This breadth of continuing pemivibart activity highlights Invivyd’s industry-leading efforts to generate and advance high quality, variation-resistant COVID-19 antibody medicines. “At Invivyd, we combine surveillance, predictive modeling and antibody engineering towards developing anti...