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Instil Bio Reports First Quarter 2022 Financial Results and Provides Corporate Update
Targeting completion of enrollment in registrational cohort of DELTA-1 in 2022Presenting preclinical efficacy and safety data of CoStAR platform at ASCO
About this update from Instil Bio, Inc.
[{"type":"text","content":"Targeting completion of enrollment in registrational cohort of DELTA-1 in 2022Presenting preclinical efficacy and safety data of CoStAR platform at ASCO 2022Cash runway into 2024 through key clinical data expected in 2023 DALLAS, May 16, 2022 (GLOBE NEWSWIRE) -- Instil Bio, Inc. (“Instil” or the “Company”) (Nasdaq: TIL), a clinical-stage biopharmaceutical company focused on developing tumor infiltrating lymphocyte, or TIL, therapies for the treatment of patients with cancer, today reported its first quarter 2022 financial results and provided a corporate update. First Quarter 2022 Highlights and Anticipated Milestones: Enrollment Ongoing in DELTA-1, a Phase 2 trial of ITIL-168 in advanced melanoma with registrational intent: Instil is targeting completion of enrollment by 2022 for the registrational cohort and expects top-line safety and efficacy data in 2023, which could potentially support a biologics license application (BLA) submission and a European Medicines Agency marketing authorization application (MAA) filing.On track with DELTA-2, a Phase 1 trial of ITIL-168 with pembrolizumab in additional cancers with unmet need: Study is expected to initiate in non-small cell lung cancer (NSCLC), cervical cancer and squamous cell carcinoma of head and neck (HNSCC) in the second quarter of 2022. The study will evaluate ITIL-168 with pembrolizumab in patients who have failed standard therapies.Readiness to Initiate Phase 1 Study of ITIL-306, the first product candidate from the CoStAR platform, in the second quarter: Instil is on track to initiate a Phase 1 study of ITIL-306, its first genetically engineered TIL using the CoStAR platform in the second quarter of 2022. Presenting Preclinical Data on the CoStAR Platform at ASCO 2022: Instil plans to present in vivo and supporting in vitro data at the 2022 ASCO Annual Meeting. Abstract details are below:Title: Antitumor activity of T cells expressing a novel anti-folate receptor alpha (FOLR1) costimulatory antigen receptor (CoStAR) in a human xenograft murine solid tumor model and implications for in-human studies. Presenting Product Characterization Data From Unmodified TILs in Cutaneous Melanoma: Instil plans to present advanced correlative analyses on TIL products administered to patients in a compassionate use program at the 25th Annual ASGCT meeting. Abstract details are below:Titl...