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INOVIO Pharmaceuticals Reports 2019 Fourth Quarter and Year-End Financial Results
PLYMOUTH MEETING, Pa., March 12, 2020 /PRNewswire/ -- INOVIO Pharmaceuticals, Inc. (NASDAQ: INO), a biotechnology company focused on rapidly bringing to
About this update from Inovio Pharmaceuticals, Inc.
[{"type":"text","content":"PLYMOUTH MEETING, Pa., March 12, 2020 /PRNewswire/ -- INOVIO Pharmaceuticals, Inc. (NASDAQ: INO), a biotechnology company focused on rapidly bringing to market precisely designed DNA medicines to treat, cure, and protect people from diseases associated with HPV, cancer, and infectious diseases, today reported financial results for the fourth quarter and year ended December 31, 2019. INOVIO's management will host a live conference call and webcast at 4:30 p.m. Eastern Time today to discuss financial results and provide a general business update.\nINOVIO Highlights\nVGX-3100: Cervical, vulvar, and anal HSIL\nREVEAL 2 Phase 3 clinical trial evaluating VGX-3100 for treatment of HPV-related cervical high-grade squamous intraepithelial lesions (HSIL) has a total of 43 sites opened globally for recruitment, which includes newly opened sites in Brazil and South Africa, along with four new U.S.-based sites. Top-line efficacy data from REVEAL 1 Phase 3 clinical trial is expected to be reported by the fourth quarter of 2020.\nINOVIO is also evaluating VGX-3100 in two Phase 2 trials for the treatment of vulvar HSIL and anal HSIL. Preliminary efficacy and safety data are planned to be presented later this month at The American Society for Colposcopy and Cervical Pathology (ASCCP) 2020 Scientific Meeting on Anogenital & HPV-Related Diseases.\nINO-3107: Recurrent respiratory papillomatosis (RRP)\nIn February 2020, INOVIO announced that the U.S. Food and Drug Administration (FDA) accepted its Investigational New Drug (IND) application to evaluate INO-3107 in a Phase 1/2 trial for treatment of recurrent respiratory papillomatosis (RRP). The Phase 1/2 trial is expected to enroll approximately 63 subjects in the United States and will evaluate the efficacy, safety, tolerability, and immunogenicity of INO-3107 in subjects with HPV 6 and/or 11-associated RRP who have required at least two surgical interventions per year for the past three years for the removal of associated papilloma(s). As RRP is a rare, orphan disease, INOVIO plans to work with the FDA's Office of Orphan Products Development (OOPD) in an effort to attain Orphan Disease designation for INO-3107.\nINOVIO and its collaborators published data from a pilot, compassionate use clinical trial for the treatment of RRP in the scientific journal Vaccines (MDPI). The article, entitled \"Immun...