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INOVIO Announces Acceptance of Abstract for Oral Presentation on INO-4201 as an Ebola Booster for rVSV-ZEBOV (Ervebo®) at ECCMID 2023
Immunological data from recently completed Phase 1b trial will be presented on April 16th PLYMOUTH MEETING, Pa., April 12, 2023 /PRNewswire/ -- INOVIO
About this update from Inovio Pharmaceuticals, Inc.
[{"type":"text","content":"Immunological data from recently completed Phase 1b trial will be presented on April 16th\nPLYMOUTH MEETING, Pa., April 12, 2023 /PRNewswire/ -- INOVIO (NASDAQ:INO), a biotechnology company focused on developing and commercializing DNA medicines to help treat and protect people from HPV-associated diseases, cancer, and infectious diseases, today announced that an abstract has been accepted for presentation for INO-4201 as an Ebola booster for rVSV-ZEBOV (Ervebo) at the 33rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID).\n\"We are pleased that lead investigator Dr. Angela Huttner will have the opportunity to share important new humoral and cellular response data at ECCMID from our recently completed Phase 1b trial of INO-4201 as an Ebola booster vaccine candidate for Ervebo,\" said Dr. Laurent Humeau, INOVIO's Chief Scientific Officer.\nDetails of the ECCMID presentation are as follows:\nTitle: Safety and immunogenicity of the DNA vaccine candidate INO-4201 followed by electroporation as booster vaccination in healthy, rVSV-ZEBOV-primed volunteers: an investigator-initiated phase 1b, placebo-controlled, randomized clinical trial (Boost-EBOV)Abstract Number: MMK0202Session: Late-breaking trial results for COVID and other viral infectionsSession Date and Time: Sunday, April 16, 8:30-10:30 am CESTLocation: Hall K\nThe data to be presented comes from a Phase 1b trial spearheaded by Global Urgent and Advanced Research and Development (GuardRX), sponsored by Geneva University Hospitals, and funded by the U.S. Defense Advanced Research Projects Agency. Dr Huttner is an Infectious Disease Consultant at Geneva University Hospitals.\nAbout INO-4201\nINO-4201 is a DNA vaccine targeting Zaire Ebola virus (ZEBOV) glycoprotein (GP), designed to prevent ZEBOV infection. INO-4201 encodes for a synthetic consensus antigen that encompasses ZEBOV genetic variability from various outbreak strains to broaden immune coverage for divergent ZEBOV variants.\nINO-4201 was evaluated in a 46-participant randomized, placebo-controlled Phase 1b trial (NCT04906629) to assess its safety, tolerability, and immunogenicity in healthy adult participants who previously received a single injection of Ervebo, a vaccine approved by the U.S. Food and Drug Administration for the prevention of disease caused by Zaire ebolavirus in individuals...