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Innovation Pharmaceuticals Reports p53 Drug Candidate Therapeutic Potential Further Supported by Academic Research in Leukemias and in Combination with Cancer Immunotherapies
Innovation Pharmaceuticals Reports p53 Drug Candidate Therapeutic Potential Further Supported by Academic Research in Leukemias and in Combination with Cancer Immunotherapies.
About this update from Innovation Pharmaceuticals Inc.
[{"type":"text","content":"\nBEVERLY, Mass., April 16, 2019 (GLOBE NEWSWIRE) -- Innovation Pharmaceuticals (OTCQB:IPIX) (“the Company”), a clinical stage biopharmaceutical company, is pleased to report recent academic and pre-clinical research further supports the therapeutic potential of Kevetrin, the Company’s p53 drug candidate, in leukemias and in combination with cancer immunotherapies. Kevetrin has been successfully evaluated in a Phase 1 clinical trial in advanced solid tumors and a Phase 2a clinical trial in late-stage ovarian cancer.\n Kevetrin and Acute Myeloid Leukemia Building on data presented at the 2017 European Hematological Association (EHA) Annual Meeting by independent cancer researchers and their conclusion—“Our results suggest Kevetrin is a promising new drug in AML patients treatment, both in wild type and, even more, in TP53 mutated tumors, through different molecular mechanisms, giving more therapeutic alternatives in the treatment of this disease.”—the Company has been notified that a related scientific article is under review for publication by a leading oncology journal. The paper details Kevetrin’s treatment potential in Acute Myeloid Leukemia (AML) by targeting p53 and several key leukemia-related genes. AML accounts for approximately one-third of all leukemias worldwide and has a 5-year survival rate of only 25 percent. Kevetrin and Cancer Immunotherapies After decades of efforts to fight cancer, both pharmaceutical industry and academic researchers have realized that single target approaches to tumor suppression are largely insufficient to stop the adaptive and progressive nature of tumorigenesis. Newer immunotherapies that leverage the body’s innate immune system have been demonstrated to be effective, increasingly part of the standard-of-care in many cancer treatments, but are associated with significant limitations. Notably, current PD-1 and PD-L1 inhibitors have been shown to be effective only in a smaller subset of cancer patients treated (10 to 30 percent) and in a limited number of tumor types. Responders can also relapse months to years after therapy. Immune checkpoint inhibitors (ICIs) can exhibit significant toxicity, including triggering immune-based attacks on the gastrointestinal tract and in the lungs in a large percentage of patients. Further, ICIs appear o...