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Study Results of Novel TYK2 Inhibitor Soficitinib in Patients with AD Published by JAMA Dermatology
BEIJING, Jan. 29, 2026 (GLOBE NEWSWIRE) -- JAMA Dermatology recently published the results of a Phase II study of novel TYK2 inhibitor soficitinib (ICP-332) in patients with moderate-to-severe atopic dermatitis (AD). The journal concluded that soficitinib demonstrated a favorable safety profile and encouraging efficacy, supporting further development for AD. This is a double-blind, placebo-controlled, phase 2 randomized clinical trial aiming to evaluate the safety and efficacy of soficitinib for
About this update from Innocare Pharma Ltd. Class A
[{"type":"image","alt":"InnoCare Pharma","displaySize":"","headline":null,"caption":"InnoCare Pharma","className":"","disableSlideshowImg":false,"size":{"original":{"width":300,"height":116,"url":"https://media.zenfs.com/en/globenewswire.com/1885e93031454229063957b3a9d6b6ec"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/_HX0Yb8ZoWwOiU8iDHIydw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTQyMDtoPTE2MjtjZj13ZWJw/https://media.zenfs.com/en/globenewswire.com/1885e93031454229063957b3a9d6b6ec","width":300,"height":116}},"lazy":false},{"type":"text","content":"BEIJING, Jan. 29, 2026 (GLOBE NEWSWIRE) -- JAMA Dermatology recently published the results of a Phase II study of novel TYK2 inhibitor soficitinib (ICP-332) in patients with moderate-to-severe atopic dermatitis (AD). The journal concluded that soficitinib demonstrated a favorable safety profile and encouraging efficacy, supporting further development for AD.","length":360,"tagName":"p"},{"type":"text","content":"This is a double-blind, placebo-controlled, phase 2 randomized clinical trial aiming to evaluate the safety and efficacy of soficitinib for moderate to severe AD. 75 participants were randomized 1:1:1 to receive soficitinib at 80 mg or 120 mg, or placebo orally once daily. The primary endpoint was safety and efficacy. The key efficacy endpoint was the percentage change from baseline in Eczema Area and Severity Index (EASI) at week 4. Other endpoints included percentages of patients achieving EASI-75 (a ≥75% improvement in EASI) and Validated Investigator Global Assessment for Atopic Dermatitis score of clear (0) or almost clear (1) with 2 or more points improvement.","length":674,"tagName":"p"},{"type":"text","content":"Soficitinib achieved multiple efficacy endpoints in the study. Percentage improvement from baseline in EASI at week 4 were 78.2% in the 80-mg soficitinib group, 72.5% in the 120-mg soficitinib group, and 16.7% for those receiving placebo. There was a statistically significant higher EASI-75 response rate with both soficitinib doses (64.0% for each; difference vs placebo, 56.0%) than with placebo and a greater percentage of Validated Investigator Global Assessment for Atopic Dermatitis score of 0 or 1 and improvement of 2 or more points at week 4 in the 80-mg soficitinib group vs placebo (36.0%; difference vs placebo, 32.0%, P=0.005).","length":641,"tagName":"p"},{"type":"text","content":"Meanw...