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USPTO Issues Patent Covering Use of XPro™ for Treatment of CNS Diseases
Boca Raton, Florida, June 22, 2022 (GLOBE NEWSWIRE) -- INmune Bio, Inc. (NASDAQ: INMB) (the “Company”), a clinical-stage immunology company focused on
About this update from Inmune Bio Inc.
[{"type":"text","content":"Boca Raton, Florida, June 22, 2022 (GLOBE NEWSWIRE) -- INmune Bio, Inc. (NASDAQ: INMB) (the “Company”), a clinical-stage immunology company focused on developing treatments that harness the patient’s innate immune system to fight disease, announces the issuance of U.S. Pat. No. 11,365,229 for “METHODS OF TREATING NEUROLOGICAL DISEASES,” a patent directed to use of Dominant Negative Tumor Necrosis Factor (DN-TNF) variants, such as the Company’s XPro™, by peripheral administration for crossing the blood-brain barrier (BBB) and treating diseases of the Central Nervous System (CNS). The patent is currently set to provide coverage through September 10, 2033, subject to a possible patent term extension if requested by the Company and approved by the USPTO under 35 U.S.C. 156. “The issuance of this patent adds significant value to the Company’s intellectual property position, as it covers the use of DN-TNF compositions by peripheral administration for all diseases of the CNS,” said Joshua Schoonover, the Company’s Associate General Counsel. “This patent is the product of real-life data using DN-TNF in both pre-clinical studies and the completed human Phase I study in Alzheimer’s Disease. DN-TNF crosses the BBB to decrease neuroinflammation, decrease neurodegeneration, improve synaptic function and promote myelin repair.” XPro™ is administered to the patient once a week as a subcutaneous injection. XPro™ is different from currently approved TNF inhibitors because it blocks only soluble TNF and leaves trans-membrane TNF alone whereas existing TNF inhibitors block both forms of TNF. Because of this biologic precision, Xpro™ is not immunosuppressive and prevents demyelination. “We believe that the unique mechanism of XPro™ makes it ideal to treat neurodegenerative diseases such as Alzheimer’s disease,” said RJ Tesi MD, CEO of INmune Bio. “Because the drug is self-administered as a once-a-week subcutaneous injection, the patients or their care-givers can administer XPro™ at home.” The Company is developing XProTM, a pegylated DN-TNF composition also known as pegipanermin for the treatment of neurological diseases, including Alzheimer’s Disease (AD), Treatment-Resistant Depression (TRD), and Amyotrophic Lateral Sclerosis (ALS). About INmune Bio, Inc. INmune Bio, Inc. is a publicly traded (NASDAQ: INMB), clinical-stage biotechnology company f...