Business
INmune Bio Inc. Publishes Novel Biology on Natural Killer Cancer Immunotherapy INKmune™ in the Journal for ImmunoTherapy of Cancer
Publication of detailed analysis on INKmune biology compared to cytokine stimulated cells demonstrates important anti-tumor memory like NK cell
About this update from Inmune Bio Inc.
[{"type":"text","content":"Publication of detailed analysis on INKmune biology compared to cytokine stimulated cells demonstrates important anti-tumor memory like NK cell characteristics BOCA RATON, Fla., July 23, 2024 (GLOBE NEWSWIRE) -- -- INmune Bio Inc. (NASDAQ: INMB) (the “Company”), a clinical-stage inflammation and immunology company developing treatments that harness the patient’s innate immune system to fight disease, announced the publication of our landmark paper in Journal Immunotherapy of Cancer co-authored by Mark Lowdell, PhD, INmune’s Chief Scientific Officer, titled, “ Proteomic and phenotypic characteristics of memory-like Natural Killer cells for cancer immunotherapy.” Link to paper: https://jitc.bmj.com/content/12/7/e008717 The study demonstrates that memory-like natural killer (mlNK) cells, generated by either cytokine or INKmuneTM priming, show increased cytotoxicity against multiple tumor types, offering promising potential for cancer immunotherapy. Importantly, while most studies are conducted on NK cells from healthy volunteers, this study demonstrated that mlNK from cancer patients are equally as potent as those generated from healthy volunteers further supporting INKmune’s in vivo treatment methodology. The research also provides new insights into the metabolic and physiological mechanisms underlying NK cell memory, paving the way for innovative treatments in both hematological malignancies and solid tumors. “The study of NK cell biology is evolving rapidly. This is the first study to identify the unique characteristics of tumor killing memory like NK cells and points to ways to enhance their potential further for cancer immunotherapy,” said Mark Lowdell PhD, CSO of INmune Bio and inventor of INKmuneTM. “INKmuneTM priming increases proteins which protect NK cells in the hostile tumor microenvironment which is exciting for our ongoing clinical trial in metastatic castration-resistant prostate cancer. This research study, led by INmune Bio, was a commercial and academic collaboration over several years and we are delighted to see it published in a high impact, peer-reviewed scientific journal.” Most significantly, this study is the first to demonstrate in vivo generation of mlNK cells; something which cannot be done with the cytokine cocktail used in vitro. The researchers successfully showed that these mlNK cells, primed by INKmu...