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INmune Bio, Inc. Announces Initiation of Clinical Program Targeting Soluble TNF to Determine if the Company’s TNF Inhibitor (DN-TNF) Platform May Prevent Complications of Cytokine Storm Caused by COVID-19
Conference call at 4:15 PM ET with management to discuss the science and strategy of clinical trial to determine if the Company’s DN-TNF platform could be
About this update from Inmune Bio Inc.
[{"type":"text","content":"Conference call at 4:15 PM ET with management to discuss the science and strategy of clinical trial to determine if the Company’s DN-TNF platform could be used to treat catastrophic complications of COVID-19 – call-in information below\n LA JOLLA, Calif., April 20, 2020 (GLOBE NEWSWIRE) -- INmune Bio, Inc. (NASDAQ: INMB) (the “Company”), an immunology company developing treatments that harness the patient’s innate immune system to fight disease, announced the initiation of a therapeutic program to treat patients with pulmonary complications from COVID-19 infection with its dominant-negative TNF inhibitor (DN-TNF) platform. Management will host a conference call on April 20th, 2020 at 4:15 PM ET to discuss the science and strategy behind its DN-TNF platform and its decision to begin the new clinical trial. The program targets patients admitted to the hospital with hypoxia who do not yet require intensive respiratory support. If successful, treatment with DN-TNF should decrease the need to transfer patients to the ICU and the need for mechanical ventilation. The Company is working closely with regulatory authorities and clinical sites to get the Phase II program enrolling patients as quickly as possible. “In response to reports highlighting the role of TNF in the cytokine storm of COVID-19 and the Lancet article, “Trials of anti-tumor necrosis factor therapy for COVID-19 are urgently needed” published earlier, INmune Bio is initiating a program to treat patients with pulmonary complications from COVID-19 infection,” said RJ Tesi MD, CEO and Chief Medical Officer of INmune Bio. “DN-TNF targets one of the main cytokines involved in cytokine storm without causing immunosuppression. The trial targets patients not yet in ICU or on mechanical ventilation in an attempt to keep them from needing these scarce resources.” Targeting soluble TNF with DN-TNF in patients with pulmonary complications from COVID-19 is based on three scientific pillars. Soluble TNF is an important part of cytokine storm and is elevated in hospitalized patients with COVID-19. Soluble TNF activates immune cells that contribute to hypoxia and acute respiratory distress syndrome (ARDS), which can result in the need for mechanical ventilation. Finally, soluble TNF activates endothelial cells to express VCAM-1 and ICAM-1 that signal leukocytes to leave the blood vessel ...