Business
INmune Bio, Inc. Announces Data on its Lead Compound Which Highlights The Potential to Lower The Risk of Alzheimer's Disease in Obese Individuals
Dr. Malú Tansey's peer-reviewed data from INmune Bio's lead compound XPro1595 published in Alzheimer's Research & Therapy LA JOLLA, Calif.,
About this update from Inmune Bio Inc.
[{"type":"text","content":"Dr. Malú Tansey's peer-reviewed data from INmune Bio's lead compound XPro1595 published in Alzheimer's Research & Therapy\nLA JOLLA, Calif., Jan. 02, 2020 (GLOBE NEWSWIRE) -- INmune Bio, Inc. (NASDAQ: INMB), an immunology company developing treatments that harness the patient’s innate immune system to fight disease, announced today the publication of new positive data in the journal Alzheimer’s Research & Therapy. The data highlights INmune Bio’s lead compound, XPro1595, as a potentially effective therapy to lower the risk for Alzheimer’s disease in obese individuals.\n “Our new data suggest that high fructose and high caloric diets impact insulin signaling and immune-metabolic interactions increasing the risk for neurodegenerative conditions such as Alzheimer’s disease,” said Malú Tansey, Ph.D., Professor of Neuroscience and Director of the Center for Translational Research in Neurodegenerative Disease at the University of Florida College of Medicine and the corresponding author of this peer-reviewed publication. “These new data suggest that XPro1595 may have therapeutic potential to block various features of Alzheimer’s- like pathology in mice.” XPro 1595 is a next-generation anti-inflammatory that can cross the blood-brain barrier to affect neurodegenerative diseases by selectively inhibiting soluble tumor necrosis factor (sTNF) and alleviate inflammation to lower the risk for Alzheimer’s disease. Dr. Tansey is an internationally recognized leader in the field of neuroinflammation and immune system responses in modulating the gene-environment interactions that determine risk for development and progression of neurodegenerative and neuropsychiatric disease. “This impressive finding coincides with the initiation of our Phase I clinical trial in Australia for patients with mild to moderate Alzheimer's disease who have biomarkers of neuroinflammation,” said R.J. Tesi, M.D., Chief Executive Officer of INmune Bio. “This data further supports the rationale of our current trial of XPro1595 as a novel way to treat Alzheimer's disease by targeting neuroinflammation which may also improve cognition and rescue neuronal communication in patients with Alzheimer’s disease.” An online version of the publication is available here: https://alzres.biomedcentral.com/articles/10.1186/s13195-019-0546-4 Facts and Figures from the Alz...