InMed Releases CBN Preclinical Results in Glaucoma

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[{"type":"text","content":"\n\n\n\nInMed Releases CBN Preclinical Results in Glaucoma\n\n/* Style Definitions */\nspan.prnews_span\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\na.prnews_a\n{\ncolor:blue;\n}\nli.prnews_li\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\np.prnews_p\n{\nfont-size:0.62em;\nfont-family:\"Arial\";\ncolor:black;\nmargin:0in;\n}\n\n\n\n\n\n\n\nCanada NewsWire\nVANCOUVER, May 27, 2020\n\n\n\nVANCOUVER, May 27, 2020 /CNW/ - InMed Pharmaceuticals Inc. (\"InMed\" or the \"Company\") (TSX:IN; OTCQX:IMLFF), a clinical-stage pharmaceutical company developing medications targeting diseases with high unmet medical need and leading the way in the clinical development of cannabinol (\"CBN\"), today provided an update on the preclinical results from its INM-088 drug development program that indicate a potential neuroprotective effect of cannabinol (\"CBN\") on nerve cells located in the eye. INM-088 is being developed as a potential treatment option for ocular diseases, such as glaucoma, where neuroprotection may provide an added therapeutic benefit.\nThe first in vitro preclinical study evaluated the neuroprotective effects of several individual cannabinoids, including CBN, tetrahydrocannabinol (\"THC\") and cannabidiol (\"CBD\"), on differentiated retinal ganglion cells, or \"RGCs\", that form a thin layer of neurons responsible for relaying visual signals in the eye. This particular study examined the effects of cannabinoids on RGCs under normal atmospheric pressure and elevated pressure conditions as a model of raised intraocular pressure (\"IOP\"), a key characteristic of glaucoma. Elevated pressure mimicking high IOP had a cytotoxic effect on the RGCs. However, the combination of CBN and elevated pressure, within the same time period, resulted in a high level of cell survival in a dose dependent fashion. CBN was superior to both CBD and THC under identical testing conditions. This data indicates a potential neuroprotective effect of CBN in ocular disease. \nNext, using the same in vitro model described above, InMed examined the potential effect of CBN on reducing or preventing natural RGC cell death, or apoptosis. Data indicate that CBN has a significant anti-apoptotic effect on differentiated RGCs subjected to elevated pressure conditions. Exposure of RGC to high pressure for a period of 6 hou...

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