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ImmunityBio Announces 12-Month Overall Survival Probability of 83% in NCI-Led Phase 1 Study of Multi-Targeted hAd5 Immunotherapy Vaccine in Patients with Advanced Metastatic Prostate Cancer
Second-generation human adenovirus (hAd5) targeting multiple tumor associated antigens (PSA, MUC-1, Brachyury) demonstrated safety, with no dose-limiting
About this update from Immunitybio, Inc.
[{"type":"text","content":"\n\nSecond-generation human adenovirus (hAd5) targeting multiple tumor associated antigens (PSA, MUC-1, Brachyury) demonstrated safety, with no dose-limiting toxicities in patients with advanced prostate cancer\n\n\n\nPositive immune activation to PSA, MUC-1, and Brachyury with 100% of 17 patients evaluated mounting T-cell responses to at least one of these tumor-associated antigens encoded by the vaccine\n\n\n\nPreliminary signals of activity include a 60% disease control rate of at least six months and a 12-month probability of survival of 83% with median survival not yet reached\n\n\n CULVER CITY, Calif.--(BUSINESS WIRE)--\nImmunityBio, Inc. (NASDAQ: IBRX), a clinical-stage immunotherapy company, today announced the publication of Phase I data in The Journal of ImmunoTherapy of Cancer (JITC). The publication, titled “Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/ brachyury-based immunotherapy vaccine in patients with metastatic castration-resistant prostate cancer (mCRPC)” highlighted the safety, T-cell immunogenicity, and clinical activity of ImmunityBio’s second-generation human adenovirus (hAd5) in patients with incurable mCRPC. ImmunityBio’s hAd5 is designed to deliver tumor-associated antigens, or TAAs, and neoepitopes (expressed only by cancer cells) and has the capability to induce T-cell memory due to the activation of both CD4+ and CD8+ T cells along with antibody (or humoral) responses.\n\n“The finding of T-cell-mediated immunity induced in 100% of 17 prostate cancer patients whose white blood cells were evaluated in the study validates the ability of our hAd5 vaccine platform to generate a potent response to antigens delivered,” said Patrick Soon-Shiong, M.D., Founder and Executive Chairman of ImmunityBio. “Furthermore, the demonstration that the vaccine can be administered repeatedly, without adverse effects at the dose of 5x 1011 viral particles, supports the application of this hAd5 platform in both cancer and infectious diseases such as COVID-19. These early results, which include signals of clinical activity and durable stable disease, are encouraging for patients with highly resistant advanced metastatic prostate cancer and warrants further study.”\n\nStudy Highlights:\n\n\nEligible patients had to have incurable metastatic castration-resistant metastatic prostate cancer with radiologic evidence ...