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Immix Biopharma Reports 2nd Positive Interim Clinical Trial Data Readout in Relapsed/Refractory Metastatic Colorectal Cancer in Ongoing Phase 1b/2a IMX-110 IMMINENT-01 Clinical Trial
Tumor shrinkage was observed in 3 out of 4 (75%) patients; 1 out of 4 (25%) experienced tumor control as of the July 7, 2023 clinical data cutoff date. All
About this update from Immix Biopharma, Inc.
[{"type":"text","content":" Tumor shrinkage was observed in 3 out of 4 (75%) patients; 1 out of 4 (25%) experienced tumor control as of the July 7, 2023 clinical data cutoff date. All patients had stage IV relapsed/refractory metastatic colorectal cancer and received 8 median lines of therapy prior to IMX-110 + tislelizumabDose Escalation Proceeding: dosing of 2nd dose cohort complete; no drug-related severe adverse events were observed, enabling enrollment of the next higher dose cohort with the goal of establishing the recommended phase 2 doseThe colorectal cancer market is estimated to reach approximately $31 billion by 2025 according to IndustryARC LOS ANGELES, July 17, 2023 (GLOBE NEWSWIRE) -- Immix Biopharma, Inc. (Nasdaq: IMMX) (“ImmixBio”, “Company”, “We” or “Us”), a biopharmaceutical company pioneering CAR-T cell therapies and tissue specific therapeutics targeting oncology and immuno-dysregulated diseases, today announced its 2nd positive IMX-110 interim update from the Company’s ongoing Phase 1b/2a IMMINENT-01 (NCT05840835) study of IMX-110 in combination with BeiGene's anti-PD-1 antibody tislelizumab. As of the July 7, 2023 data cutoff date, out of 4 relapsed/refractory metastatic colorectal cancer patients treated with IMX-110 + tislelizumab: 3 out of 4 (75%) patients experienced tumor shrinkage at 2 months1 out of 4 (25%) patients experienced tumor control at 2 months1 out of 4 patients remain on IMX-110 + tislelizumab therapy as of July 7, 2023Median progression-free survival and overall survival not yet reachedPatients received a median of 8 earlier anti-cancer treatments that failed to halt cancer growth (lines of therapy) prior to receiving IMX-110 + tislelizumab and all 4 had proficient mismatch repair (pMMR) relapsed/refractory mCRCIMMINENT-01 continues to enroll the next cohort of patients at a higher dose “We are encouraged that in these early cohorts of patients receiving just a fraction of what we believe will be the optimal dose, we continue to see signals of activity of IMX-110 in relapsed/refractory metastatic colorectal cancer patients that received a median of 8 lines of anti-cancer therapies that failed to halt cancer growth prior to receiving IMX-110 + tislelizumab,” said Ilya Rachman, MD PhD, Chief Executive Officer of Immix Biopharma. “In the subsequent higher dose cohorts of IMMINENT-01, we are hopeful that clinical resul...