Business
Hoth Therapeutics and Zylö Therapeutics Finalize Agreement
NEW YORK, Aug. 21, 2019 /PRNewswire/ -- Hoth Therapeutics, Inc. (Nasdaq: HOTH), a biopharmaceutical company focused on unique targeted therapeutics for
About this update from Hoth Therapeutics, Inc.
[{"type":"text","content":" NEW YORK, Aug. 21, 2019 /PRNewswire/ -- Hoth Therapeutics, Inc. (Nasdaq: HOTH), a biopharmaceutical company focused on unique targeted therapeutics for patients suffering from dermatological indications ranging from atopic dermatitis to chronic wound disorders, today announced it has entered into a definitive partnership agreement with Zylö Therapeutics to develop a new treatment for patients suffering from Cutaneous Lupus Erythematosus [CLE], a chronic autoimmune disease that affects the skin.\n\n \nZylö Therapeutics, dedicated to bringing innovative topical technologies to multiple facets of medicine, has developed a patented topical delivery system using xerogel-derived nanoparticles called Z-pods™ s, Hoth has an exclusive license to develop Anandamide-loaded Z-pods™ for the treatment of CLE in North America. Anandamide, generally referred to as AEA, is one of the cannabinoids that the human body makes naturally.\nHoth also has certain rights related to geographic expansion and to follow-on indications such as psoriasis and rheumatoid arthritis. \nScientists at the Albert Einstein College of Medicine, where the platform technology was originally developed, have demonstrated that topical administration with AEA-loaded Z-pods™ inhibits the development of CLE lesions in a well-established animal model of lupus. This work reinforces and highlights the utility of targeting the endocannabinoid system for autoimmune rheumatic diseases.\nThe work at Einstein supports the thesis that AEA-loaded Z-pods™:\nimprove drug penetration prevent the development of skin lesions improve skin histopathology reduce macrophages and C3 accumulation reduce inflammatory cytokine secretion by keratinocytes have no deleterious effect on antibody levelsAccording to estimates by the Lupus Foundation of America [LFA], 1.5 million Americans currently suffer from lupus, with 16,000 new cases reported annually; tragically, lupus strikes mostly women of child-bearing age and is 2-3 times more prevalent amongst women of color. Worldwide, the LFA estimates that at least five million people have some form of the disease. Of those diagnosed, approximately two-thirds will develop CLE. The average cost to provide medical treatment for a person with lupus is well over $10,000 per year.\n\"Zylö's initial work with AEA-loaded Z-pods shows significant promise in treati...