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Hemostemix Announces Phase II Results Plus New Heart Study Demonstrating Statistically Significant Improvement in Ejection Fraction at 4 and 12 Months after ACP-01 Heart Injections
Calgary, Alberta--(Newsfile Corp. - August 30, 2022) - Hemostemix Inc. (TSXV: HEM) (OTCQB: HMT...
About this update from Hemostemix Inc
[{"type":"text","content":"Hemostemix Announces Phase II Results Plus New Heart Study Demonstrating Statistically Significant Improvement in Ejection Fraction at 4 and 12 Months after ACP-01 Heart InjectionsCalgary, Alberta--(Newsfile Corp. - August 30, 2022) - Hemostemix Inc. (TSXV: HEM) (OTCQB: HMTXF) (FSE: 2VF0) (\"Hemostemix\" or the \"Company\") is pleased to announce the results of its Phase II Clinical Trial and the results of a new retrospective study of patients that underwent a trans-catheter, intramyocardial injection of angiogenic cell precursors (ACP-01) as a treatment for heart failure (ischemic and non-ischemic dilated cardiomyopathy).The 2021 American Heart Association estimated the prevalence of heart failure (HF) in the United States to be 6 million; within 5-years of hospitalization, the death rate amongst this population is approximately 50%. ACP-01 in its capacity to replace damaged cells, secrete growth factors, stimulate angiogenesis and exert an anti-inflammatory effect to minimize scarring, have emerged as a therapeutic option. Hemostemix has just completed an IRB approved, retrospective, outcomes study to analyse the effect of ACP-01 implants on cardiac function in patients with severe heart failure (New York Heart association Grades 3 and 4). Cardiac function was measured in terms of ejection fraction of the left ventricle (LVEF %; normal range ≥55%). At first follow-up (average 4 months) after ACP-01 cell implantation, for all types of heart failure, the LVEF was increased by 4.6% (from 28.6% to 33.2%), representing a statistically significant improvement (p = 0.0011). On final follow-up (average 12 months after cell implantation) for all patients, the LVEF% had improved by 7.69%, which was statistically significant (p=0.003). When analyzing ischemic heart failure alone (n=41), LVEF increased from 29.9% before implantation, to 34.5%, and to 38.2% at final follow-up, for an overall improvement of 8.37%, which was statistically significant (p= 0.003). There was greater improvement in the non-ischemic dilated cardiomyopathy patients (n=8), who improved from 25.94% before treatment to 40.29% at final follow-up, for an overall improvement of 14.35% (p=0. 002).Figure 1To view an enhanced version of Figure 1, please visit:https://images.newsfilecorp.com/files/5065/135348_02b6afe174792b9b_002full.jpgTo determine whether the...