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GT Biopharma Provides Update Concerning Trike(TM) Drug Development Programs and Other Strategic Initiatives
BEVERLY HILLS, CA / ACCESSWIRE / January 21, 2020 / GT Biopharma, Inc. (OTCQB:GTBP) (GTBP.PA) an immuno-oncology company focused on innovative treatments
About this update from Gt Biopharma, Inc.
[{"type":"text","content":"BEVERLY HILLS, CA / ACCESSWIRE / January 21, 2020 / GT Biopharma, Inc. (OTCQB:GTBP) (GTBP.PA) an immuno-oncology company focused on innovative treatments based on the Company's proprietary TriKE™ NK cell engager platform provided the following update concerning its drug development programs and certain other initiatives:The Company recently commenced enrollment in its first-in-human GTB-3550 TriKE™ Phase I/II clinical trial for the treatment of certain types of leukemia. The clinical trial is being conducted at the University of Minnesota's Masonic Cancer Center in Minneapolis, Minnesota under the direction of Dr. Erica Warlick. The open-label, dose-escalation Phase I portion of the trial will evaluate GTB-3550 TriKE™ in patients with CD33-expressing, high risk myelodysplastic syndromes, refractory/relapsed acute myeloid leukemia or advanced systemic mastocytosis, and will determine safety and tolerability as well as the pharmacologically active dose and maximum tolerated dose of GTB-3550 TriKE™. The Phase II portion of the trial is planned to further evaluate the recommended dose of GTB-3550 TriKE™ in this patient population.Dr. Jeffrey Miller and colleagues from the University of Minnesota presented research results concerning the development of an HIV TriKE™ which directs NK cell killing of HIV-infected CD4 T-cells. Dr. Miller and colleagues presented their HIV TriKE™ research at the 18th meeting of the Society for Natural Immunity held in Luxembourg September 30th to October 3rd, 2019. The data demonstrated that natural killer (NK) cells are stimulated by the human IL-15 cytokine portion of the TriKE™ molecule which provided a self-sustaining signal, activating NK cells and enhancing their ability to kill. The data also demonstrated that the HIV TriKE™ was able to reactive HIV replication in latent HIV-infected CD4+ T-cells. These findings indicate a potential role for the HIV-TriKE™ in the reactivation and elimination of the latently infected HIV reservoir cells by harnessing the NK cell's ability to mediate antibody-directed cellular cytotoxicity (ADCC).Drs. Jeffrey Miller, Martin Felices and Pippa Kennedy from the University of Minnesota presented TriKE™ research results at the recently concluded 18th meeting of the Society for Natural Immunity concerning the development of a solid tumor targeting TriKE™ which demonstrate...