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GT Biopharma Presents Two Posters at the Society for Immunotherapy of Cancer’s (SITC) 37th Annual Meeting
Poster #1: Tri-specific killer engagers target natural killer cells towards mesotheliomaPoster #2: Enhancing NK cell function in the 'cold' tumor
About this update from Gt Biopharma, Inc.
[{"type":"text","content":"Poster #1: Tri-specific killer engagers target natural killer cells towards mesotheliomaPoster #2: Enhancing NK cell function in the 'cold' tumor microenvironment of prostate cancer with a novel Tri-specific Killer Engager against prostate-specific membrane antigen (PSMA) BRISBANE, CALIFORNIA, Nov. 10, 2022 (GLOBE NEWSWIRE) -- GT Biopharma, Inc. (the “Company” or “GTB”) (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company's proprietary natural killer (NK) cell engager, TriKE® platform, will present two poster presentations at the Society for Immunotherapy of Cancer’s 37th Annual Meeting (SITC 2022), to be held in Boston, Massachusetts and virtually on November 8-12, 2022. The two posters highlight tri-specific killer engagers for the treatment of mesothelioma and prostate cancer. “We are pleased with the progress that has been made in assessing the broad applicability of our novel TriKE platform across solid tumors” said Michael Breen, Executive Chairman and Interim CEO of GT Biopharma. “Our TriKE structure consisting of an anti-CD16 nanobody which binds to NK cells and triggers antibody directed cell-mediated cytotoxicity (ADCC), IL-15 cross-linker that binds to NK cells inducing self-sustaining expansion and extended survival and an anti-tumor associated antigen which binds to well-known tumor antigens. The TriKE modular platform allows for targeting multiple tumor-associated antigens. As such, we remain excited in our progress to date while looking forward to submitting an Investigational New Drug (IND) application in 2023 for lead assets GTB-3650 targeting CD33 positive tumors and GTB-5550 targeting B7H3 positive tumors, respectively.” Presentation Highlights: Abstract #1202: Tri-specific killer engagers target natural killer cells towards mesothelioma Presenter: Martin FelicesDate: November 11, 2022Location and time: Poster Hall from 9:00am – 8:30pm ET Mesothelioma is a rare cancer, most cases are of the cell lining of the lung as a result of asbestos exposure and in fewer cases, the lining of the abdomen wall. The study examined two novel TriKEs targeting mesothelin (cam1615SS1) commonly found on epithelioid mesothelioma, and a second TriKE targeting B7H3 (GTB-5550), a common tumor antigen.TriKEs cam1615SSS1 and GTB-5550 were tested across multiple meso...